Preparation and controlled-release study of ethyl cellulose-moxa leaf powder solution microcapsules

Abstract

文章首次以乙基纤维素为壁材,采用溶剂蒸发法制得艾叶粉水溶液微胶囊。正交实验得出制备微胶囊的最佳工艺条件为:乙基纤维素︰芯材︰乙酸乙酯︰水相=1︰2.5︰13︰130(质量比),搅拌速度:1500 r/min,乳化时间:15 mim,水油两相混合搅拌时间:10 min。通过扫描电镜表征结果显示,所得微胶囊固体颗粒呈球形,分散性好,粒径在20～200μm范围内。实验制得微胶囊最大载药量为48.07%,具有良好的包覆效果。透析缓释实验表明,微胶囊在37.0℃恒温生理盐水浸泡60 h后,仍有艾叶药理活性成分存在,较好地延长了储藏时间和药物有效作用时限。 In the paper,moxa leaf powder solution microcapsules were firstly prepared by solvent evaporation method with ethyl cellulose as shell material.Orthogonal experiments showed that the best processing conditions of the microcapsules was: ethyl cellulose︰sandwich material︰ethyl acetate︰aqueous phase=1 ︰2.5︰13︰130(mass ratio),stirring at 1500 r/min,dispersed of 15 min,water/oil mixed of 10 min.Scanning electron microscopy(SEM)were used to characterize of microcapsules.The particle size wad spherical,dispersibility and diameters of 20～200 μm.Microcapsules allowed a better encapsulation of moxa leaf powder solution and the best drug load was 48.07 %.The controlled-release experiment proved that after immersing in normal saline for 60 h under constant temperature of 37 ℃,the activity of moxa leaf powder solution was preserved.