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Title: Ginseng extracts restore high-glucose induced vascular dysfunctions by altering triglyceride metabolism and downregulation of atherosclerosis-related genes
Authors: Chan, GHH
Law, BYK
Chu, JMT
Yue, KKM
Jiang, ZH
Lau, CW
Huang, Y
Chan, SW
Yue, PYK
Wong, RNS
Issue Date: 2013
Publisher: Hindawi Publishing Corporation
Source: Evidence-based complementary and alternative medicine, 2013, v. 2013, 797310, p. 1-13 How to cite?
Journal: Evidence-based complementary and alternative medicine 
Abstract: The king of herbs, Panax ginseng, has been used widely as a therapeutic agent vis-`a-vis its active pharmacological and physiological effects. Based on Chinese pharmacopeia Ben Cao Gang Mu and various pieces of literature, Panax ginseng was believed to exert active vascular protective effects through its antiobesity and anti-inflammation properties.We investigated the vascular protective effects of ginseng by administrating ginseng extracts to rats after the induction of diabetes. We found that Panax ginseng can restore diabetes-induced impaired vasorelaxation and can reduce serum triglyceride but not cholesterol level in the diabetic rats. Theginseng extracts also suppressed the expression of atherosclerosis-related genes and altered the expression of lipid-related genes. The results provide evidence that Panax ginseng improves vascular dysfunction induced by diabetes and the protective effects may possibly be due to the downregulation of atherosclerosis-related genes and altered lipid metabolism, which help to restore normal endothelium functions.
ISSN: 1741-427X
EISSN: 1741-4288
DOI: 10.1155/2013/797310
Rights: Copyright © 2013 Gabriel Hoi-huen Chan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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