Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/6007
Title: | Ginseng extracts restore high-glucose induced vascular dysfunctions by altering triglyceride metabolism and downregulation of atherosclerosis-related genes | Authors: | Chan, GHH Law, BYK Chu, JMT Yue, KKM Jiang, ZH Lau, CW Huang, Y Chan, SW Yue, PYK Wong, RNS |
Issue Date: | 2013 | Source: | Evidence-based complementary and alternative medicine, 2013, v. 2013, 797310, p. 1-13 | Abstract: | The king of herbs, Panax ginseng, has been used widely as a therapeutic agent vis-`a-vis its active pharmacological and physiological effects. Based on Chinese pharmacopeia Ben Cao Gang Mu and various pieces of literature, Panax ginseng was believed to exert active vascular protective effects through its antiobesity and anti-inflammation properties.We investigated the vascular protective effects of ginseng by administrating ginseng extracts to rats after the induction of diabetes. We found that Panax ginseng can restore diabetes-induced impaired vasorelaxation and can reduce serum triglyceride but not cholesterol level in the diabetic rats. Theginseng extracts also suppressed the expression of atherosclerosis-related genes and altered the expression of lipid-related genes. The results provide evidence that Panax ginseng improves vascular dysfunction induced by diabetes and the protective effects may possibly be due to the downregulation of atherosclerosis-related genes and altered lipid metabolism, which help to restore normal endothelium functions. | Publisher: | Hindawi Publishing Corporation | Journal: | Evidence-based complementary and alternative medicine | ISSN: | 1741-427X | EISSN: | 1741-4288 | DOI: | 10.1155/2013/797310 | Rights: | Copyright © 2013 Gabriel Hoi-huen Chan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
eCAM-2013-3.pdf | 3.32 MB | Adobe PDF | View/Open |
Page views
136
Last Week
1
1
Last month
Citations as of Apr 21, 2024
Downloads
157
Citations as of Apr 21, 2024
SCOPUSTM
Citations
15
Last Week
0
0
Last month
0
0
Citations as of Apr 4, 2024
WEB OF SCIENCETM
Citations
14
Last Week
1
1
Last month
0
0
Citations as of Apr 18, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.