A new inference approach for joint models of longitudinal data with informative observation and censoring times

Abstract

For the analysis of longitudinal data, Liang, Lu, and Ying (Biometrics (2009)) proposed a novel joint model to capture the relation between the longitudinal response process and the observation times through latent variables, and developed an estimation procedure under the assumptions that the distributions of the latent variables are specified and the censoring times are noninformative. This may not be true in practice, and here we propose a new estimation procedure for their model that does not require these assumptions. Estimating equation approaches are developed for parameter estimation, and the resulting estimators are shown to be consistent and asymptotically normal. In addition, some procedures are presented for model selection and model checking. Simulation studies demonstrate that the proposed method performs well and an application to a bladder cancer study is provided.