Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/55481
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Guo, J | - |
dc.creator | Wang, J | - |
dc.creator | Gao, S | - |
dc.creator | Ji, B | - |
dc.creator | Chan, WCE | - |
dc.creator | Chen, S | - |
dc.date.accessioned | 2016-09-07T02:22:00Z | - |
dc.date.available | 2016-09-07T02:22:00Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/55481 | - |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.rights | The following publication Guo, J. et al. Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxication. Sci. Rep. 5, 16981 (2015) is available at https://dx.doi.org/10.1038/srep16981 | en_US |
dc.title | Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against botulinum neurotoxin a intoxication | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 5 | - |
dc.identifier.doi | 10.1038/srep16981 | - |
dcterms.abstract | Potent inhibitors to reverse Botulinum neurotoxins (BoNTs) activity in neuronal cells are currently not available. A better understanding of the substrate recognition mechanism of BoNTs enabled us to design a novel class of peptide inhibitors which were derivatives of the BoNT/A substrate, SNAP25. Through a combination of in vitro, cellular based, and in vivo mouse assays, several potent inhibitors of approximately one nanomolar inhibitory strength both in vitro and in vivo have been identified. These compounds represent the first set of inhibitors that exhibited full protection against BoNT/A intoxication in mice model with undetectable toxicity. Our findings validated the hypothesis that a peptide inhibitor targeting the two BoNT structural regions which were responsible for substrate recognition and cleavage respectively could exhibit excellent inhibitory effect, thereby providing insight on future development of more potent inhibitors against BoNTs. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Scientific reports, 20 2015, v. 5, no. , p. 1-8 | - |
dcterms.isPartOf | Scientific reports | - |
dcterms.issued | 2015 | - |
dc.identifier.scopus | 2-s2.0-84947800739 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.rosgroupid | 2015001038 | - |
dc.description.ros | 2015-2016 > Academic research: refereed > Publication in refereed journal | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Guo_Substrate-based_Inhibitors_Exhibiting.pdf | 923.2 kB | Adobe PDF | View/Open |
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