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Title: Mammographic breast density in Chinese women : spatial distribution and autocorrelation patterns
Authors: Lai, CWK 
Law, HKW 
Issue Date: 2015
Source: PLoS one, 2015, v. 10, no. 9, e0136881
Abstract: Mammographic breast density (MBD) is a strong risk factor for breast cancer. The spatial distribution of MBD in the breast is variable and dependent on physiological, genetic, environmental and pathological factors. This pilot study aims to define the spatial distribution and autocorrelation patterns of MBD in Chinese women aged 40-60. By analyzing their digital mammographic images using a public domain Java image processing program for segmentation and quantification of MBD, we found their left and right breasts were symmetric to each other in regard to their breast size (Total Breast Area), the amount of BMD (overall PD) and Moran's I values. Their MBD was also spatially autocorrelated together in the anterior part of the breast in those with a smaller breast size, while those with a larger breast size tend to have their MBD clustered near the posterior part of the breast. Finally, we observed that the autocorrelation pattern of MBD was dispersed after a 3-year observation period.
Publisher: Public Library of Science
Journal: PLoS one 
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0136881
Rights: © 2015 Lai, Law. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The following publication: Lai CWK, Law HKW (2015) Mammographic Breast Density in Chinese Women: Spatial Distribution and Autocorrelation Patterns. PLoS ONE 10(9): e0136881 is available at
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