Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/54601
DC FieldValueLanguage
dc.contributorDepartment of Rehabilitation Sciences-
dc.creatorSánchez-Vidaña, DI-
dc.creatorChan, NMJ-
dc.creatorChan, AHL-
dc.creatorHui, KKY-
dc.creatorLee, S-
dc.creatorChan, HY-
dc.creatorLaw, YS-
dc.creatorSze, MY-
dc.creatorTsui, WCS-
dc.creatorFung, TKH-
dc.creatorLau, BWM-
dc.creatorLai, CYY-
dc.date.accessioned2016-08-17T02:05:56Z-
dc.date.available2016-08-17T02:05:56Z-
dc.identifier.issn0306-4522-
dc.identifier.urihttp://hdl.handle.net/10397/54601-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectOxytocinen_US
dc.subjectHippocampal cell proliferationen_US
dc.subjectNeurogenesisen_US
dc.subjectDendritic complexityen_US
dc.subjectDepression-like behaviorsen_US
dc.subjectAnxiety-like behaviorsen_US
dc.titleRepeated treatment with oxytocin promotes hippocampal cell proliferation, dendritic maturation and affects socio-emotional behavioren_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage65-
dc.identifier.epage77-
dc.identifier.volume333-
dc.identifier.doi10.1016/j.neuroscience.2016.07.005-
dcterms.abstractRewarding social behaviors including positive social interactions and sexual behaviors are shown to regulate adult neurogenesis, but the underlying biological mechanisms remain elusive. Oxytocin, a neurohypophysial hormone secreted after exposure to social interaction or sexual behaviors, has a profound role in the formation of social bonding and regulation of emotional distress. While the acute effect of oxytocin was usually studied, relatively scarce evidence showed the behavioral consequence of repeated oxytocin treatment. The purpose of the current study was to investigate the effect of repeated oxytocin treatment on hippocampal cell proliferation, dendritic maturation of new born neurons and social/emotional behaviors. Adult male Sprague–Dawley rats received treatment with either vehicle or oxytocin (1 mg/kg) daily for two weeks. Behavioral tests revealed that oxytocin increased social behaviors and reduced the anxiety- and depression-like behaviors. Cell proliferation, differentiation and the dendritic complexity of new born neurons in the hippocampus were promoted by oxytocin treatment. Depression- and anxiety-like behaviors were induced by repeated treatment of corticosterone (40 mg/kg) for two weeks while oxytocin treatment reversed the behavioral disturbances. Suppression of cell proliferation caused by corticosterone was reverted by oxytocin treatment in which cell proliferation, cell differentiation, and dendritic complexity increased. The present findings reveal that oxytocin not only enhances cell proliferation, but also promotes the development of the new neurons which is associated with the induction of positive emotional and social behaviors. The results also suggest that oxytocin may be a potential therapeutic agent for treatment of emotional and social dysfunction.-
dcterms.bibliographicCitationNeuroscience,1 Oct. 2016, v. 333, p. 65-77-
dcterms.isPartOfNeuroscience-
dcterms.issued2016-10-01-
dc.identifier.rosgroupid2015001352-
dc.description.ros2015-2016 > Academic research: refereed > Publication in refereed journal-
Appears in Collections:Journal/Magazine Article
Access
View full-text via PolyU eLinks SFX Query
Show simple item record

SCOPUSTM   
Citations

22
Last Week
0
Last month
Citations as of Aug 14, 2020

WEB OF SCIENCETM
Citations

24
Last Week
0
Last month
Citations as of Oct 21, 2020

Page view(s)

267
Last Week
4
Last month
Citations as of Oct 18, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.