Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/53666
PIRA download icon_1.1View/Download Full Text
Title: Implications of MicroRNAs in the treatment of gefitinib-resistant non-small cell lung cancer
Authors: Sin, TK
Wang, FF
Meng, F
Wong, SCC 
Cho, WCS
Siu, PM 
Chan, LWC 
Issue Date: Feb-2016
Source: International journal of molecular sciences, Feb. 2016, v. 17, no. 2, 237, p. 1-13
Abstract: Non-small cell lung cancer (NSCLC) represents about 85% of the reported cases of lung cancer. Acquired resistance to targeted therapy with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, is not uncommon. It is thus vital to explore novel strategies to restore sensitivity to gefitinib. Provided that microRNAs (miRNAs) negatively regulate their gene targets at the transcriptional level, it is speculated that miRNA mimetics may reduce the expression, activity and signal transduction of EGFR so that sensitization of tumour sites to gefitinib-induced cytotoxicity can be achieved. Indeed, a growing body of evidence has shown that the manipulation of endogenous levels of miRNA not only attenuates the EGFR/PI3K/Akt phosphorylation cascade, but also restores apoptotic cell death in in vitro models of experimentally-induced gefitinib resistance and provoked tumour regression/shrinkage in xenograft models. These data are in concordant with the clinical data showing that the differential expression profiles of miRNA in tumour tissues and blood associate strongly with drug response and overall survival. Furthermore, another line of studies indicate that the chemopreventive effects of a variety of natural compounds may involve miRNAs. The present review aims to discuss the therapeutic capacity of miRNAs in relation to recent discoveries on EGFR-TKI resistance, including chronic drug exposure and mutations.
Keywords: EGFR
Gefitinib
miRNA
Non-small cell lung cancer
Resistance
Publisher: Molecular Diversity Preservation International (MDPI)
Journal: International journal of molecular sciences 
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms17020237
Rights: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
The following Molecular Diversity Preservation International (MDPI) publication Sin, T. K., Wang, F., Meng, F., Wong, S. C., Cho, W., Siu, P. M., ... & Yung, B. Y. (2016). Implications of MicroRNAs in the Treatment of Gefitinib-Resistant Non-Small Cell Lung Cancer. International journal of molecular sciences, 17(2), 237 is available at http://dx.doi.org/10.3390/ijms17020237
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
ijms-17-00237.pdf438.68 kBAdobe PDFView/Open
Open Access Information
Status open access
File Version Version of Record
Access
View full-text via PolyU eLinks SFX Query
Show full item record

Page views

248
Last Week
1
Last month
Citations as of Mar 24, 2024

Downloads

116
Citations as of Mar 24, 2024

SCOPUSTM   
Citations

50
Last Week
0
Last month
Citations as of Mar 29, 2024

WEB OF SCIENCETM
Citations

45
Last Week
0
Last month
Citations as of Mar 28, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.