Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/5262
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Liu, Q | - |
dc.creator | Tong, Y | - |
dc.creator | Sze, SCW | - |
dc.creator | Liu, WK | - |
dc.creator | Lam, L | - |
dc.creator | Chu, ESM | - |
dc.creator | Yow, CMN | - |
dc.date.accessioned | 2014-12-11T08:24:46Z | - |
dc.date.available | 2014-12-11T08:24:46Z | - |
dc.identifier.issn | 1749-8546 | - |
dc.identifier.uri | http://hdl.handle.net/10397/5262 | - |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central Ltd. | en_US |
dc.rights | © 2010 Liu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.title | Tian Xian Liquid (TXL) induces apoptosis in HT-29 colon cancer cell in vitro and inhibits tumor growth in vivo | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 7 | - |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 25 | - |
dc.identifier.doi | 10.1186/1749-8546-5-25 | - |
dcterms.abstract | Background: Tian Xian Liquid (TXL) is a Chinese medicine decoction and has been used as an anticancer dietary supplement. The present study aims to investigate the effects of TXL on the apoptosis of HT-29 cells and tumor growth in vivo. | - |
dcterms.abstract | Method: HT-29 colon cancer cells were treated with gradient dilution of TXL. The mitochondrial membrane potential was measured by JC-1 assay. The release of cytochrome c from mitochondrial and apoptosis-related proteins Bax, Bcl-2, cleaved caspase-3, 9 were examined by Western blot analysis. HT-29 cells were implanted in nude mice to examine the effects of TXL on tumor growth. | - |
dcterms.abstract | Result: TXL inhibited HT-29 xenografted model and showed a strong and dose-dependent inhibitory effect on the proliferation of HT-29 cells. Mitochondrial membrane potential was reduced by TXL at the concentration of 0.5% above. For Western blot analysis, an increase in Bax expression and a decrease in Bcl-2 expression were observed in TXL-treated cells. TXL treatment increased the protein level of cleaved casepase-3 and caspase-9, and the release of cytochrome c in cytoplasm was up-regulated as well. | - |
dcterms.abstract | Conclusion: TXL significantly inhibits cell proliferation in the HT-29 cells and HT-29 xenografted model via the mitochondrial cell death pathway. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Chinese medicine, 21 July 2010, v. 5, no. 25, p. 1-7 | - |
dcterms.isPartOf | Chinese medicine | - |
dcterms.issued | 2010-07-21 | - |
dc.identifier.scopus | 2-s2.0-77954669821 | - |
dc.identifier.pmid | 20663169 | - |
dc.identifier.rosgroupid | r53361 | - |
dc.description.ros | 2010-2011 > Academic research: refereed > Publication in refereed journal | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Liu_Tian_Xian_liquid.pdf | 1.41 MB | Adobe PDF | View/Open |
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