Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/43798
Title: Preparation and characterization of paclitaxel loaded SF/PLLA-PEG-PLLA nanoparticles via solution-enhanced dispersion by supercritical CO2
Authors: Zhao, Z 
Li, Y 
Zhang, Y 
Issue Date: 2015
Publisher: Hindawi Publishing Corporation
Source: Journal of nanomaterials, 2015, v. 2015, 913254 How to cite?
Journal: Journal of nanomaterials 
Abstract: Paclitaxel loaded silk fibroin/PLLA-PEG-PLLA (PTX-SF/PLLA-PEG-PLLA) nanoparticles with a mean particle size of about 651 nm were fabricated successfully by the SEDS process. Fourier transform infrared (FTIR) spectroscopy analysis indicated that the PTX was encapsulated by SF/PLLA-PEG-PLLA nanoparticles. X-ray powder diffraction (XRPD) analysis supported the results of FTIR analysis and also suggested that the crystalline state of PTX was decreased obviously. Furthermore, the UV-Vis/HPLC analysis showed that drug load (DL) and encapsulation efficiency (EE) were 18.1% and 90.2%, respectively. The in vitro drug release experiment suggested that the PTX-SF/PLLA-PEG-PLLA nanoparticles exhibited a sustained release and only 16.1% and 24.5% of paclitaxel were released at pH 7.4 and 6.0, respectively, in one week. The PTX-SF/PLLA-PEG-PLLA nanoparticles drug delivery system with pH-dependent release property has potential application in the field of tumor therapy.
URI: http://hdl.handle.net/10397/43798
ISSN: 1687-4110
EISSN: 1687-4129
DOI: 10.1155/2015/913254
Rights: Copyright © 2015 Zheng Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following article: Zhao, Z., Li, Y., & Zhang, Y. (2015). Preparation and characterization of paclitaxel loaded SF/PLLA-PEG-PLLA nanoparticles via solution-enhanced dispersion by supercritical CO 2. Journal of Nanomaterials, 2015, 6, is available at https//doi.org/10.1155/2015/913254
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