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Title: | 骨组织中降钙素基因相关肽阳性神经的分布及生理作用 | Authors: | 王晓云 Guo, X Qian, ZM |
Issue Date: | Mar-2005 | Source: | 中华骨科杂志 (Chinese journal of orthopedics), Mar. 2005, v. 25, no. 3, p. 185-188 | Abstract: | 降钙素 (calcitonin,CT)和降钙素基因相关肽(calcitonin gene-relatedpeptide,CGRP)均由降钙素基因(calcitoningene)编码。CT是调节骨代谢的重要激素。早在1961年 Copp等[1]就发现并命名了CT。其后的研究发现CT主要由甲状腺C细胞分泌,可与破骨细胞膜上的CT受体结合来抑制骨吸收[2]。因此,近年来CT 多用于治疗骨吸收活跃的骨病[3],如骨质疏松症、Paget病等。CGRP阳性神经纤维广泛分布于全身各组织内,包括骨组织[4,5]。越来越多的研究 发现CGRP也参与调节骨生长、修复及改建[6]。CGRP是1983年由Rosenfeld等 | Publisher: | 天津骨科硏究所 | Journal: | 中华骨科杂志 (Chinese journal of orthopedics) | ISSN: | 0253-2352 | Rights: | © 2005 China Academic Journal Electronic Publishing House. It is to be used strictly for educational and research use. © 2005 中国学术期刊电子杂志出版社。本内容的使用仅限于教育、科研之目的。 |
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