Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/36352
Title: Novel bioactive antimicrobial lignin containing coatings on titanium obtained by electrophoretic deposition
Authors: Erakovic, S
Jankovic, A
Tsui, GCP 
Tang, CY 
Miskovic-Stankovic, V
Stevanovic, T
Issue Date: 2014
Source: International journal of molecular sciences, July 2014, v. 15, no. 7, p. 12294-12322
Abstract: Hydroxyapatite (HAP) is the most suitable biocompatible material for bone implant coatings; its brittleness, however, is a major obstacle, and the reason why research focuses on creating composites with biopolymers. Organosolv lignin (Lig) is used for the production of composite coatings, and these composites were examined in this study. Titanium substrate is a key biomedical material due to its well-known properties, but infections of the implantation site still impose a serious threat. One approach to prevent infection is to improve antimicrobial properties of the coating material. Silver doped hydroxyapatite (Ag/HAP) and HAP coatings on titanium were obtained by an electrophoretic deposition method in order to control deposited coating mass and morphology by varying applied voltage and deposition time. The effect of lignin on microstructure, morphology and thermal behavior of biocomposite coatings was investigated. The results showed that higher lignin concentrations protect the HAP lattice during sintering, improving coating stability. The corrosion stability was evaluated in simulated body fluid (SBF) at 37 degrees C. Newly formed plate-shaped carbonate-HAP was detected, indicating enhanced bioactive performance. The antimicrobial efficiency of Ag/HAP/Lig was confirmed by its higher reduction of bacteria Staphylococcus aureus TL (S. aureus TL) than of HAP/Lig coating. Cytotoxicity assay revealed that both coatings can be classified as non-toxic against healthy immunocompetent peripheral blood mononuclear cells (PBMC).
Keywords: Organosolv lignin
Silver
Hydroxyapatite
Electrophoretic deposition
Titanium
Bioactivity
SBF
Cytotoxicity
Antimicrobial activity
Publisher: Molecular Diversity Preservation International (MDPI)
Journal: International journal of molecular sciences 
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms150712294
Rights: © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
The following publication Erakovic, S.; Jankovic, A.; Tsui, G.C.P.; Tang, C.-Y.; Miskovic-Stankovic, V.; Stevanovic, T. Novel Bioactive Antimicrobial Lignin Containing Coatings on Titanium Obtained by Electrophoretic Deposition. Int. J. Mol. Sci. 2014, 15, 12294-12322 is available at https://dx.doi.org/10.3390/ijms150712294
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