Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/36208
Title: Cortex Fraxini (Qingpi) protects Rat Pheochromocytoma cells against 6-Hydroxydopamine-induced Apoptosis
Authors: Li, JJ
Zhou, SY
Zhang, H
Lam, KH
Lee, SMY
Yu, PHF
Chan, SW
Issue Date: 2015
Publisher: Hindawi Publishing Corporation
Source: Parkinson's disease, 2015, 532849 How to cite?
Journal: Parkinson's disease 
Abstract: Parkinson's disease (PD) is a chronic neurodegenerative disorder having close relationship with oxidative stress induced by reactive oxygen species (ROS). Cortex Fraxini (QP) is a kind of traditional Chinese medicinal herb with antioxidant properties. It may be a potential candidate for preventing the development of chronic neurodegenerative diseases. Thus, the key objective of the current study was to investigate the neuroprotective effect of QP water extract on 6-hydroxydopamine (6-OHDA) induced apoptosis in rat pheochromocytoma (PC12) cells. It was found that QP water extract possesses strong antioxidant property with SC50 = 0.15 mg/mL. Total phenolic content of QP water extract was found to be 200.78 +/- 2.65 mg GAE/g. QP water extract's free radical scavenging capacity was demonstrated by reversing the increased level of intracellular ROS induced by 6-OHDA, using 2',7'-dichlorodihydrofluorescein diacetate. Moreover, QP water extract (0.5mg/mL) could remarkably increase the viability of PC12 cells treated with 6-OHDA. The protective effect of QP water extract was found to be via inhibiting MEK/ERK pathway and reversing PI3-K/Akt/GSK3 beta pathway. The current results suggest that QP might be a potential candidate for preventing the development of neurodegenerative diseases, such as PD.
URI: http://hdl.handle.net/10397/36208
ISSN: 2090-8083 (print)
2042-0080 (online)
DOI: 10.1155/2015/532849
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