Please use this identifier to cite or link to this item:
Title: Cortex Fraxini (Qingpi) protects Rat Pheochromocytoma cells against 6-Hydroxydopamine-induced Apoptosis
Authors: Li, JJ
Zhou, SY
Zhang, H
Lam, KH
Lee, SMY
Chan, SW
Issue Date: 2015
Publisher: Hindawi Publishing Corporation
Source: Parkinson's disease, 2015, 532849 How to cite?
Journal: Parkinson's disease 
Abstract: Parkinson's disease (PD) is a chronic neurodegenerative disorder having close relationship with oxidative stress induced by reactive oxygen species (ROS). Cortex Fraxini (QP) is a kind of traditional Chinese medicinal herb with antioxidant properties. It may be a potential candidate for preventing the development of chronic neurodegenerative diseases. Thus, the key objective of the current study was to investigate the neuroprotective effect of QP water extract on 6-hydroxydopamine (6-OHDA) induced apoptosis in rat pheochromocytoma (PC12) cells. It was found that QP water extract possesses strong antioxidant property with SC50 = 0.15 mg/mL. Total phenolic content of QP water extract was found to be 200.78 +/- 2.65 mg GAE/g. QP water extract's free radical scavenging capacity was demonstrated by reversing the increased level of intracellular ROS induced by 6-OHDA, using 2',7'-dichlorodihydrofluorescein diacetate. Moreover, QP water extract (0.5mg/mL) could remarkably increase the viability of PC12 cells treated with 6-OHDA. The protective effect of QP water extract was found to be via inhibiting MEK/ERK pathway and reversing PI3-K/Akt/GSK3 beta pathway. The current results suggest that QP might be a potential candidate for preventing the development of neurodegenerative diseases, such as PD.
ISSN: 2090-8083 (print)
2042-0080 (online)
DOI: 10.1155/2015/532849
Appears in Collections:Journal/Magazine Article

View full-text via PolyU eLinks SFX Query
Show full item record


Citations as of Jan 6, 2017

Page view(s)

Last Week
Last month
Checked on Jan 15, 2017

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.