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http://hdl.handle.net/10397/35066
Title: | Adherence therapy versus routine psychiatric care for people with schizophrenia spectrum disorders : a randomised controlled trial | Authors: | Chien, WT Mui, J Gray, R Cheung, E |
Issue Date: | 25-Feb-2016 | Source: | BMC psychiatry, 2016, v. 16:42, p. 1-14 | Abstract: | Background: Current practice guidelines for schizophrenia care recommend that antipsychotic medication is essential for patients’ long-term maintenance treatment but their non-adherence to this medication is still a main obstacle to relapse prevention. This study evaluated the effects of a motivational-interviewing-based adherence therapy for people with schizophrenia spectrum disorders. Methods: This randomised controlled trial was conducted with 134 outpatients with schizophrenia spectrum disorders; 67 of them received a six-session adherence therapy (in addition to usual care) and 67 received usual psychiatric care alone. Participants’ outcome measures included symptom severity, medication adherence, hospitalisation rates, insight into illness/treatment, and functioning. Results: The adherence therapy group reported significantly greater improvements in symptom severity (p < 0.003), insight into illness/treatment (p < 0.001), functioning (p < 0.005), duration of re-hospitalisations (p < 0.005), and medication adherence (p < 0.005) over 18 months follow-up, when compared with usual care alone. Conclusions: Motivational-interviewing-based adherence therapy can be an effective approach to treatment for people with early stage of schizophrenia who poorly adhere to medication regimen. Trial registration: ClinicalTrials.gov NCT01780116, registration date January 29, 2013. |
Keywords: | Adherence therapy Antipsychotics Motivational interviewing Randomised controlled trial Schizophrenia Insight into treatment |
Publisher: | BioMed Central Ltd. | Journal: | BMC psychiatry | EISSN: | 1471-244X | DOI: | 10.1186/s12888-016-0744-6 | Rights: | © 2016 Chien et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
Appears in Collections: | Journal/Magazine Article |
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Chien_Adherence_Therapy_Routine.pdf | 1.57 MB | Adobe PDF | View/Open |
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