Please use this identifier to cite or link to this item:
Title: Adherence therapy versus routine psychiatric care for people with schizophrenia spectrum disorders : a randomised controlled trial
Authors: Chien, WT 
Mui, J
Gray, R
Cheung, E
Keywords: Adherence therapy
Motivational interviewing
Randomised controlled trial
Insight into treatment
Issue Date: 25-Feb-2016
Publisher: BioMed Central Ltd.
Source: BMC psychiatry, 2016, v. 16:42, p. 1-14 How to cite?
Journal: BMC psychiatry 
Abstract: Background: Current practice guidelines for schizophrenia care recommend that antipsychotic medication is essential for patients’ long-term maintenance treatment but their non-adherence to this medication is still a main obstacle to relapse prevention. This study evaluated the effects of a motivational-interviewing-based adherence therapy for people with schizophrenia spectrum disorders.
Methods: This randomised controlled trial was conducted with 134 outpatients with schizophrenia spectrum disorders; 67 of them received a six-session adherence therapy (in addition to usual care) and 67 received usual psychiatric care alone. Participants’ outcome measures included symptom severity, medication adherence, hospitalisation rates, insight into illness/treatment, and functioning.
Results: The adherence therapy group reported significantly greater improvements in symptom severity (p < 0.003), insight into illness/treatment (p < 0.001), functioning (p < 0.005), duration of re-hospitalisations (p < 0.005), and medication adherence (p < 0.005) over 18 months follow-up, when compared with usual care alone.
Conclusions: Motivational-interviewing-based adherence therapy can be an effective approach to treatment for people with early stage of schizophrenia who poorly adhere to medication regimen. Trial registration: NCT01780116, registration date January 29, 2013.
EISSN: 1471-244X
DOI: 10.1186/s12888-016-0744-6
Rights: © 2016 Chien et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
Chien_Adherence_Therapy_Routine.pdf1.57 MBAdobe PDFView/Open
View full-text via PolyU eLinks SFX Query
Show full item record
PIRA download icon_1.1View/Download Contents


Last Week
Last month
Citations as of Jul 31, 2018


Last Week
Last month
Citations as of Aug 3, 2018

Page view(s)

Last Week
Last month
Citations as of Aug 14, 2018


Citations as of Aug 14, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.