Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/35066
Title: Adherence therapy versus routine psychiatric care for people with schizophrenia spectrum disorders : a randomised controlled trial
Authors: Chien, WT 
Mui, J
Gray, R
Cheung, E
Keywords: Adherence therapy
Antipsychotics
Motivational interviewing
Randomised controlled trial
Schizophrenia
Insight into treatment
Issue Date: 25-Feb-2016
Publisher: BioMed Central Ltd.
Source: BMC psychiatry, 2016, v. 16:42, p. 1-14 How to cite?
Journal: BMC psychiatry
Abstract: Background: Current practice guidelines for schizophrenia care recommend that antipsychotic medication is essential for patients’ long-term maintenance treatment but their non-adherence to this medication is still a main obstacle to relapse prevention. This study evaluated the effects of a motivational-interviewing-based adherence therapy for people with schizophrenia spectrum disorders.
Methods: This randomised controlled trial was conducted with 134 outpatients with schizophrenia spectrum disorders; 67 of them received a six-session adherence therapy (in addition to usual care) and 67 received usual psychiatric care alone. Participants’ outcome measures included symptom severity, medication adherence, hospitalisation rates, insight into illness/treatment, and functioning.
Results: The adherence therapy group reported significantly greater improvements in symptom severity (p < 0.003), insight into illness/treatment (p < 0.001), functioning (p < 0.005), duration of re-hospitalisations (p < 0.005), and medication adherence (p < 0.005) over 18 months follow-up, when compared with usual care alone.
Conclusions: Motivational-interviewing-based adherence therapy can be an effective approach to treatment for people with early stage of schizophrenia who poorly adhere to medication regimen. Trial registration: ClinicalTrials.gov NCT01780116, registration date January 29, 2013.
URI: http://hdl.handle.net/10397/35066
ISSN: 1471-244X (online)
DOI: 10.1186/s12888-016-0744-6
Rights: © 2016 Chien et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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