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Title: | Adaptive responses of TRPC1 and TRPC3 during skeletal muscle atrophy and regrowth | Authors: | Zhang, BT Yeung, SS Cheung, KK Chai, ZY Yeung, EW |
Issue Date: | May-2014 | Source: | Muscle and nerve, May 2014, v. 49, no. 5, p. 691-699 | Abstract: | Introduction: We assessed the time-dependent changes of transient receptor potential canonical type 1 (TRPC1) and TRPC3 expression and localization associated with muscle atrophy and regrowth in vivo. Methods: Mice were subjected to hindlimb unloading for 7 or 14 days (7U, 14U) followed by 3, 7, or 14 days of reloading (3R, 7R, 14R). Results: Soleus muscle mass and tetanic force were reduced significantly at 7U and 14U and recovered by 14R. Recovery of muscle fiber cross-sectional area was observed by 28R. TRPC1 mRNA was unaltered during the unloading-reloading period. However, protein expression remained depressed through 14R. Decreased localization of TRPC1 to the sarcolemma was observed. TRPC3 mRNA and protein expression levels were decreased significantly during the early phase of reloading. Conclusions: Given the known role of these channels in muscle development, changes observed in TRPC1 and TRPC3 may relate closely to muscle atrophy and remodeling processes. |
Keywords: | Hindlimb suspension Muscle atrophy Muscle regeneration TRPC1 TRPC3 |
Publisher: | John Wiley & Sons | Journal: | Muscle and nerve | ISSN: | 0148-639X | EISSN: | 1097-4598 | DOI: | 10.1002/mus.23952 | Rights: | Copyright © 2013 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Zhang, B.‐T., Yeung, S.S., Cheung, K.‐K., Chai, Z.Y. and Yeung, E.W. (2014), Adaptive responses of TRPC1 and TRPC3 during skeletal muscle atrophy and regrowth. Muscle and Nerve, 49: 691-699, which has been published in final form at https://doi.org/10.1002/mus.23952. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Posted with permission of the publisher. |
Appears in Collections: | Journal/Magazine Article |
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a0657-n15_767_Zhang_Muscle_Nerve.pdf | Pre-Published version | 1.5 MB | Adobe PDF | View/Open |
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