Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/33812
Title: Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2
Authors: Zhao, Z
Xie, M
Li, Y 
Chen, A
Li, G
Zhang, J
Hu, H 
Wang, X
Li, S
Keywords: Crystalline sate
Curcumin
Dissolution rate
Solubility
Issue Date: 2015
Publisher: Dove Medical Press
Source: International journal of nanomedicine, 2015, v. 10, p. 3171-3181 How to cite?
Journal: International journal of nanomedicine 
Abstract: In order to enhance the bioavailability of poorly water-soluble curcumin, solution-enhanced dispersion by supercritical carbon dioxide (CO2) (SEDS) was employed to prepare curcumin nanoparticles for the first time. A 24 full factorial experiment was designed to determine optimal processing parameters and their infuence on the size of the curcumin nanoparticles. Particle size was demonstrated to increase with increased temperature or fow rate of the solution, or with decreased precipitation pressure, under processing conditions with different parameters considered. The single effect of the concentration of the solution on particle size was not significant. Curcumin nanoparticles with a spherical shape and the smallest mean particle size of 325 nm were obtained when the following optimal processing conditions were adopted: P =20 MPa, T =35¢XC, fow rate of solution =0.5 mL?min-1, concentration of solution =0.5%. Fourier transform infrared (FTIR) spectroscopy measurement revealed that the chemical composition of curcumin basically remained unchanged. Nevertheless, X-ray powder diffraction (XRPD) and thermal analysis indicated that the crystalline state of the original curcumin decreased after the SEDS process. The solubility and dissolution rate of the curcumin nanoparticles were found to be higher than that of the original curcumin powder (approximately 1.4 £gg/mL vs 0.2 £gg/mL in 180 minute
URI: http://hdl.handle.net/10397/33812
ISSN: 1176-9114
EISSN: 1178-2013
DOI: 10.2147/IJN.S80434
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