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Title: Lessons learnt from evidence-based approach of using Chinese herbal medicines in liver cancer
Authors: Zheng, Z
Cho, WCS
Xu, L
Wang, J
Sze, DMY 
Issue Date: 2013
Publisher: Hindawi Publishing Corporation
Source: Evidence-based complementary and alternative medicine, 2013, v. 2013, 656351 How to cite?
Journal: Evidence-based complementary and alternative medicine 
Abstract: This paper is a systematic review of evidence-based studies of the effectiveness of Chinese herbal medicine (CHM) in the treatment of liver cancer. After a detailed analysis of the literature, five animal studies and four human clinical trials met the criteria for inclusion. Analysis revealed that results of the clinical trials, whilst encouraging, need to be interpreted with caution as problems with study designs may lead to apparent benefits being attributable to various forms of bias. However, as each of the CHM agents used in these studies appeared to be potentially beneficial, further well-designed and controlled randomized clinical trials are warranted. The second part of this review focused on the lessons learned from the relationships between Traditional Chinese Medicine (TCM) theory, TCM Syndrome Differentiation, and modern scientific understanding of mechanisms of action of CHM agents. The understanding of TCM Syndrome Differentiation may allow identification of different patterns of disharmony and may provide important guidance to the prescription of CHM. Furthermore, quality control using both biological and chemical fingerprinting of CHM is important to ensure batch-to-batch consistency to deliver sustained therapeutic benefit. Also, careful assessment of herb-drug interactions is paramount for safety and integrative use of western chemotherapeutic and CHM agents.
ISSN: 1741-427X
EISSN: 1741-4288
DOI: 10.1155/2013/656351
Rights: Copyright © 2013 Zhan Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following article: Zhan Zheng, William Chi-Shing Cho, Ling Xu, Juyong Wang, and Daniel Man-Yuen Sze, “Lessons Learnt from Evidence-Based Approach of Using Chinese Herbal Medicines in Liver Cancer,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 656351, 11 pages, 2013, is available at
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