Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/33309
Title: Multiple regression analysis of mRNA-miRNA associations in colorectal cancer pathway
Authors: Wang, F
Wong, SCC 
Chan, LWC 
Cho, WCS
Yip, SP 
Yung, BYM 
Issue Date: 2014
Publisher: Hindawi Publishing Corporation
Source: BioMed research international, 2014, v. 2014, 676724 How to cite?
Journal: BioMed research international 
Abstract: Background. MicroRNA (miRNA) is a short and endogenous RNA molecule that regulates posttranscriptional gene expression. It is an important factor for tumorigenesis of colorectal cancer (CRC), and a potential biomarker for diagnosis, prognosis, and therapy of CRC. Our objective is to identify the related miRNAs and their associations with genes frequently involved in CRC microsatellite instability (MSI) and chromosomal instability (CIN) signaling pathways. Results. A regression model was adopted to identify the significantly associated miRNAs targeting a set of candidate genes frequently involved in colorectal cancer MSI and CIN pathways. Multiple linear regression analysis was used to construct the model and find the significant mRNA-miRNA associations. We identified three significantly associated mRNA-miRNA pairs: BCL2 was positively associated with miR-16 and SMAD4 was positively associated with miR-567 in the CRC tissue, while MSH6 was positively associated with miR-142-5p in the normal tissue. As for the whole model, BCL2 and SMAD4 models were not significant, and MSH6 model was significant. The significant associations were different in the normal and the CRC tissues. Conclusion. Our results have laid down a solid foundation in exploration of novel CRC mechanisms, and identification of miRNA roles as oncomirs or tumor suppressor mirs in CRC.
URI: http://hdl.handle.net/10397/33309
ISSN: 2314-6133
EISSN: 2314-6141
DOI: 10.1155/2014/676724
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

10
Last Week
0
Last month
1
Citations as of Sep 19, 2017

WEB OF SCIENCETM
Citations

9
Last Week
0
Last month
1
Citations as of Sep 14, 2017

Page view(s)

42
Last Week
4
Last month
Checked on Sep 18, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.