Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/32051
Title: | Effect of lycium barbarum (Wolfberry) on alleviating axonal degeneration after partial optic nerve transection | Authors: | Li, HY Ruan, YW Kau, PWF Chiu, K Chang, RCC Chan, HHL So, KF |
Issue Date: | 1-Mar-2015 | Source: | Cell transplantation, 1 Mar. 2015, v. 24, no. 3, p. 403-417 | Abstract: | Our previous results showed that the polysaccharides extracted from Lycium barbarum (LBP) could delay secondary degeneration of retinal ganglion cell bodies and improve the function of the retinas after partial optic nerve transection (PONT). Although the common degeneration mechanisms were believed to be shared by both neuronal bodies and axons, recently published data from slow Wallerian degeneration mutant (Wlds) mice supported the divergence in the mechanisms of them. Therefore, we want to determine if LBP could also delay the degeneration of axons after PONT. Microglia/macrophages were thought to be a source of reactive oxygen species after central nervous system (CNS) injury. After PONT, however, oxidative stress was believed to occur prior to the activation of microglia/macrophages in the areas vulnerable to secondary degeneration both in the optic nerves (ONs) and the retinas. But the results did not take into account the morphological changes of microglia/macrophages after their activation. So we examined the morphology in addition to the response magnitude of microglia/macrophages to determine their time point of activation. In addition, the effects of LBP on the activation of microglia/macrophages were investigated. The results showed that (1) LBP reduced the loss of axons in the central ONs and preserved the g-ratio (axon diameter/ fiber diameter) in the ventral ONs although no significant effect was detected in the dorsal ONs; (2) microglia/macrophages were activated in the ONs by 12 h after PONT; (3) LBP decreased the response magnitude of microglia/macrophages 4 weeks after PONT. In conclusion, our results showed that LBP could delay secondary degeneration of the axons, and LBP could also inhibit the activation of microglia/macrophages. Therefore, LBP could be a promising herbal medicine to delay secondary degeneration in the CNS via modulating the function of microglia/macrophages. | Keywords: | Lycium barbarum Macrophage Optic nerve (ON) Partial transection Secondary degeneration |
Publisher: | Sage Publications | Journal: | Cell Transplantation | ISSN: | 0963-6897 | DOI: | 10.3727/096368915X686896 | Rights: | Posted with permission of Cognizant Communication Corporation Copyright © 2015 Cognizant Comm. Corp. The following publication Li, H.-Y., Ruan, Y.-W., Kau, P. W.-F., Chiu, K., Chang, R. C.-C., Chan, H. H. L., & So, K.-F. (2015). Effect of Lycium barbarum (Wolfberry) on Alleviating Axonal Degeneration after Partial Optic Nerve Transection. Cell Transplantation, 403–417 is available at https://doi.org/10.3727/096368915X686896. |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
096368915x686896.pdf | 915.56 kB | Adobe PDF | View/Open |
Page views
144
Last Week
0
0
Last month
Citations as of Apr 28, 2024
Downloads
66
Citations as of Apr 28, 2024
SCOPUSTM
Citations
30
Last Week
0
0
Last month
0
0
Citations as of Apr 26, 2024
WEB OF SCIENCETM
Citations
24
Last Week
0
0
Last month
0
0
Citations as of May 2, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.