Please use this identifier to cite or link to this item:
Title: Effect of Lycium Barbarum (Wolfberry) Polysaccharides on preserving retinal function after partial optic nerve transection
Authors: Chu, PHW 
Li, HY
Chin, MP 
So, KF
Chan, HHL 
Issue Date: 2013
Publisher: Public Library of Science
Source: PLoS one, 2013, v. 8, no. 12, e81339 How to cite?
Journal: PLoS one 
Abstract: Lycium Barbarum Polysaccharides (LBP) are the active components of Wolfberry (a traditional Chinese medicine) which has long been used for improving visual function. This study aims to investigate localized changes of retinal function in a partial optic nerve transection (PONT) model, and effects of LBP on visual function. The multifocal electroretinograms (mfERG) were obtained from 30 eyes of 30 Sprague-Dawley rats. The rats were divided into 6 groups (five treatment groups and one control group). Starting from the first day of the experiment, the rats in the (PONT+LBP) group and the (LBP) group were dosed with LBP; rats in the (PONT+ PBS (phosphate buffered saline)) group and the (PBS) group were dosed with PBS via nasogastric tube every day until euthanized. The dorsal part of the optic nerve was transected in the (PONT), (PONT+LBP) and (PONT+PBS) groups at the end of week 1 (day 7 after LBP or PBS feeding began). The mfERG was measured at three time points: week 2, week 3 and week 5. Significant reduction of P1 and PhNR amplitudes of the mfERG were observed in all retinal regions a week after PONT. Feeding with LBP prior to PONT preserved retinal function. All mfERG responses returned to the normal range in the superior retina, which corresponds to the transected dorsal region of the optic nerve, while most of the inferior retinal responses were significantly increased at week 4 after PONT. The ventral part of the retina had secondary degeneration which was not only limited to the ganglion cell layer, but is a widespread effect affecting the outer retina. LBP altered the functional reduction caused by PONT by regulating the signal from the outer retina.
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0081339
Rights: © 2013 Chu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The following publication: Chu PHW, Li H-Y, Chin M-P, So K-f, Chan HHL (2013) Effect of Lycium Barbarum (Wolfberry) Polysaccharides on Preserving Retinal Function after Partial Optic Nerve Transection. PLoS ONE 8(12): e81339 is available at
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
Chu_Effect_Lycium_Barbarum.PDF5.69 MBAdobe PDFView/Open
View full-text via PolyU eLinks SFX Query
Show full item record
PIRA download icon_1.1View/Download Contents


Last Week
Last month
Citations as of Nov 16, 2018


Last Week
Last month
Citations as of Nov 19, 2018

Page view(s)

Last Week
Last month
Citations as of Nov 19, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.