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Title: A novel, stable, estradiol-stimulating, osteogenic yam protein with potential for the treatment of menopausal syndrome
Authors: Wong, LK
Lai, YM 
Li, KW
Lee, KF
Ng, TB
Cheung, HP
Zhang, YB
Lao, L
Wong, RNS
Shaw, PC
Wong, JH
Zhang, ZJ
Lam, JKW
Ye, WC
Sze, SCW
Issue Date: 2015
Publisher: Nature Publishing Group
Source: Scientific reports, 2015, v. 5, 10179 How to cite?
Journal: Scientific reports 
Abstract: A novel protein, designated as DOI, isolated from the Chinese yam (Dioscorea opposita Thunb.) could be the first protein drug for the treatment of menopausal syndrome and an alternative to hormone replacement therapy (HRT), which is known to have undesirable side effects. DOI is an acid- and thermo-stable protein with a distinctive N-terminal sequence Gly-Ile-Gly-Lys-Ile-Thr-Thr-Tyr-Trp-Gly-Gln-Tyr-Ser-Asp-Glu-Pro-Ser-Leu-Thr-Glu. DOI was found to stimulate estradiol biosynthesis in rat ovarian granulosa cells; induce estradiol and progesterone secretion in 16- to 18-month-old female Sprague Dawley rats by upregulating expressions of follicle-stimulating hormone receptor and ovarian aromatase; counteract the progression of osteoporosis and augment bone mineral density; and improve cognitive functioning by upregulating protein expressions of brain-derived neurotrophic factor and TrkB receptors in the prefrontal cortex. Furthermore, DOI did not stimulate the proliferation of breast cancer and ovarian cancer cells, which suggest it could be a more efficacious and safer alternative to HRT.
EISSN: 2045-2322
DOI: 10.1038/srep10179
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
The following publication Lok, K.W. et al. A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome. Sci. Rep. 5, 10179 is published by Nature Publishing Group and is available at
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