Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/28833
Title: Bond formation of surface-tethered receptor-ligand pairs in relative separation
Authors: Qian, J
Lin, Y
Jiang, H
Yao, H 
Issue Date: 2013
Publisher: American Institute of Physics
Source: Applied physics letters, 2013, v. 103, no. 22, 223702 How to cite?
Journal: Applied physics letters 
Abstract: We theoretically and numerically investigate the interplay between diffusion of a surface-bound receptor and its reaction with an opposing ligand. Special attention has been paid to the mechanical regulation of bond association by varying the initial gap distance and relative separation speed between the protein-bearing surfaces. Such diffusion-reaction coupling effects can cause the apparent on-rate or reciprocal of the average waiting time for bond formation, to be not constant, but instead a function sensitive to the system parameters that affect the transport of proteins. The results provide a quantitative understanding of how significantly the transport mechanism can affect overall binding behavior of molecular interactions and call for a paradigm shift in modeling receptor-ligand bond association when the protein-bearing surfaces are in relative separation.
URI: http://hdl.handle.net/10397/28833
ISSN: 0003-6951
EISSN: 1077-3118
DOI: 10.1063/1.4834915
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