Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24889
Title: Brazilin inhibits amyloid £]-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity
Authors: Du, WJ
Guo, JJ
Gao, MT
Hu, SQ
Dong, XY
Han, YF 
Liu, FF
Jiang, S
Sun, Y
Issue Date: 2015
Publisher: Nature Publishing Group
Source: Scientific reports, 2015, v. 5, 7992 How to cite?
Journal: Scientific reports 
Abstract: Soluble amyloid £]-protein (A£]) oligomers, the main neurotoxic species, are predominantly formed from monomers through a fibril-catalyzed secondary nucleation. Herein, we virtually screened an in-house library of natural compounds and discovered brazilin as a dual functional compound in both A£] 42 fibrillogenesis inhibition and mature fibril remodeling, leading to significant reduction in A£] 42 cytotoxicity. The potent inhibitory e
URI: http://hdl.handle.net/10397/24889
EISSN: 2045-2322
DOI: 10.1038/srep07992
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