Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/23892
Title: | Ultrasound evaluation of Carotid Atherosclerosis in post-radiotherapy nasopharyngeal carcinoma patients, Type 2 Diabetics, and healthy controls | Other Title: | Sonografische Bewertung der Arteriosklerose der Carotis bei Patienten mit Nasopharynxkarzinom nach Bestrahlung, Typ-2-Diabetikern und gesunden Kontrollprobanden | Authors: | Yuan, C Wu, VWC Yip, SP Kwong, DLW Ying, M |
Issue Date: | Apr-2017 | Source: | Ultraschall in der Medizin (European Journal of Ultrasound), Apr. 2017, v. 38, no. 02, p. 190-197 | Abstract: | Purpose: To comprehensively evaluate and compare the degree of carotid atherosclerosis in patients treated with radiotherapy (RT) for nasopharyngeal carcinoma (NPC) and in patients with type 2 diabetes mellitus (DM), and using healthy subjects as controls. Materials and Methods: The present study recruited 69 post-RT NPC patients without conventional cardiovascular risk factors, 70 type 2 diabetic patients without previous RT, and 76 healthy controls without conventional cardiovascular risk factors and previous RT. For each participant, 5 carotid atherosclerotic parameters, namely carotid intima-media thickness (CIMT), carotid arterial stiffness (CAS), presence of carotid plaque, carotid plaque score, and presence of ≥ 50 % carotid stenosis, were assessed using ultrasonography. The differences in these carotid atherosclerotic parameters between study groups were compared using ANCOVA or logistic regression after the adjustment for age and gender. Multiple comparisons were corrected using the Benjamini-Hochberg false discovery rate. Results: Post-RT NPC patients and type 2 diabetics had a significantly higher CIMT, CAS and carotid plaque burden compared to the healthy subjects (corrected P-value, Pcor < 0.05). In addition, carotid atherosclerosis in post-RT NPC patients tended to be more severe with significantly higher CAS and carotid plaque burden than that in type 2 diabetics (Pcor < 0.05). Conclusion: Neck RT for NPC is an independent risk factor of carotid atherosclerosis, and radiation induces more severe carotid atherosclerosis in post-RT NPC patients. Thus, assessment of carotid atherosclerosis using ultrasonography may be necessary for these patients and should be indicated in the routine follow-up of NPC. |
Keywords: | Arteriosclerosis Carotid arteries Radiation effects Tumor Ultrasound |
Publisher: | Georg Thieme Verlag | Journal: | Ultraschall in der Medizin | ISSN: | 0172-4614 | DOI: | 10.1055/s-0034-1399293 | Rights: | © Georg Thieme Verlag KG Stuttgart · New York This is the accepted version of the work. The final published article is available at https://doi.org/10.1055/s-0034-1399293. |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Wu_Ultrasound_Evaluation_Carotid.pdf | Pre-Published version | 606.34 kB | Adobe PDF | View/Open |
Page views
110
Last Week
7
7
Last month
Citations as of Mar 17, 2024
Downloads
53
Citations as of Mar 17, 2024
SCOPUSTM
Citations
14
Last Week
0
0
Last month
0
0
Citations as of Feb 29, 2024
WEB OF SCIENCETM
Citations
15
Last Week
0
0
Last month
0
0
Citations as of Mar 14, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.