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Title: A one-step method to fabricate PLLA scaffolds with deposition of bioactive hydroxyapatite and collagen using ice-based microporogens
Authors: Li, J
Chen, Y
Mak, AFT
Tuan, RS
Li, L
Li, Y 
Keywords: Ice-based microporogens
Poly(L-lactic acid)
Issue Date: Jun-2010
Publisher: Elsevier Ltd.
Source: Acta Biomaterialia, June 2010, v. 6, no. 6, p. 2013-2019 How to cite?
Journal: Acta Biomaterialia 
Abstract: Porous poly(L-lactic acid) (PLLA) scaffolds with bioactive coatings were prepared by a novel one-step method. In this process, ice-based microporogens containing bioactive molecules, such as hydroxyapatite (HA) and collagen, served as both porogens to form the porous structure and vehicles to transfer the bioactive molecules to the inside of PLLA scaffolds in a single step. Based on scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction and Fourier transform infrared spectroscopy analysis, the bioactive components were found to be transferred successfully from the porogens to PLLA scaffolds evenly. Osteoblast cells were used to evaluate the cellular behaviors of the composite scaffolds. After culturing for 8 days, MTT assay and alkaline phosphatase activity results suggested that HA/collagen could improve the interactions between osteoblast cells and the polymeric scaffold.
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2009.12.008
Rights: Acta Biomaterialia © 2010 Elsevier Ltd. The journal web site is located at
Appears in Collections:Journal/Magazine Article

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