Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/20880
Title: Biophysical insights into how spike threshold depends on the rate of membrane potential depolarization in Type I and Type II neurons
Authors: Yi, GS
Wang, J
Tsang, KM 
Wei, XL
Deng, B
Issue Date: 2015
Publisher: Public Library of Science
Source: PLoS one, 2015, v. 10, no. 6, e0130250 How to cite?
Journal: PLoS one 
Abstract: Dynamic spike threshold plays a critical role in neuronal input-output relations. In many neurons, the threshold potential depends on the rate of membrane potential depolarization (dV/dt) preceding a spike. There are two basic classes of neural excitability, i.e., Type I and Type II, according to input-output properties. Although the dynamical and biophysical basis of their spike initiation has been established, the spike threshold dynamic for each cell type has not been well described. Here, we use a biophysical model to investigate how spike threshold depends on dV/dt in two types of neuron. It is observed that Type II spike threshold is more depolarized and more sensitive to dV/dt than Type I. With phase plane analysis, we show that each threshold dynamic arises from the different separatrix and K+ current kinetics. By analyzing subthreshold properties of membrane currents, we find the activation of hyperpolarizing current prior to spike initiation is a major factor that regulates the threshold dynamics. The outward K+ current in Type I neuron does not activate at the perithresholds, which makes its spike threshold insensitive to dV/dt. The Type II K+ current activates prior to spike initiation and there is a large net hyperpolarizing current at the perithresholds, which results in a depolarized threshold as well as a pronounced threshold dynamic. These predictions are further attested in several other functionally equivalent cases of neural excitability. Our study provides a fundamental description about how intrinsic biophysical properties contribute to the threshold dynamics in Type I and Type II neurons, which could decipher their significant functions in neural coding.
URI: http://hdl.handle.net/10397/20880
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0130250
Rights: © 2015 Yi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
The following publication: Yi G-S, Wang J, Tsang K-M, Wei X-L, Deng B (2015) Biophysical Insights into How Spike Threshold Depends on the Rate of Membrane Potential Depolarization in Type I and Type II Neurons. PLoS ONE 10(6): e0130250 is available at https://doi.org/10.1371/journal.pone.0130250
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
Yi_Biophysical_insights_spike.PDF8.84 MBAdobe PDFView/Open
Access
View full-text via PolyU eLinks SFX Query
Show full item record
PIRA download icon_1.1View/Download Contents

SCOPUSTM   
Citations

5
Last Week
0
Last month
0
Citations as of Nov 6, 2018

WEB OF SCIENCETM
Citations

5
Last Week
0
Last month
0
Citations as of Nov 15, 2018

Page view(s)

89
Last Week
2
Last month
Citations as of Nov 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.