Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/20143
Title: In-vitro strain and modulus measurements in porcine cervical lymph nodes
Authors: Yuen, QWH
Zheng, YP 
Huang, YP
He, JF
Cheung, JCW
Ying, M 
Keywords: Elastography
Indentation
Lymph node
Soft tissue
Strain image
Ultrasound
Young's modulus
Issue Date: 2011
Source: Open biomedical engineering journal, 2011, v. 5, no. 1, p. 39-46 How to cite?
Journal: Open Biomedical Engineering Journal 
Abstract: Cervical lymph nodes are common sites of metastatic involvement in head and neck cancers. These lymph nodes are superficially located and palpation is a common practice for assessing nodal hardness and staging cancer which is, however, too subjective and with limited accuracy. In this study, the mechanical properties of pig lymph node tissues were investigated using ultrasound elastography and indentation test. Lymph nodes were excised from fresh pork pieces and embedded in an agar-gelatin phantom for strain imaging by elastography. A strain ratio reflecting the strain contrast of lymph node over agar-gelatin phantom was used to assess the elasticity of the lymph node. A cutting device was then custom-designed to slice the phantom into uniform slices for indentation test. The measurements revealed that there were significant differences in both the strain ratio and Young's modulus between the peripheral and middle regions of the lymph nodes (both p < 0.05); however, the results appeared contradictory. Correlation between the results of the two measurements (modulus ratio vs. inversed strain ratio) showed their association was moderate for both the peripheral and middle regions (R2 = 0.437 and 0.424 respectively). As the tests were only performed on normal lymph nodes, comparison in stiffness between healthy and abnormal lymph nodes could not be made. Future studies should be conducted to quantify the stiffness change in abnormal lymph nodes.
URI: http://hdl.handle.net/10397/20143
ISSN: 1874-1207
DOI: 10.2174/1874120701105010039
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

6
Last Week
0
Last month
0
Citations as of Oct 19, 2017

Page view(s)

51
Last Week
0
Last month
Checked on Oct 15, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.