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Title: Genetic algorithm-based PCA eigenvector selection and weighting for automated identification of dementia using FDG-PET imaging
Authors: Xia, Y
Wen, L
Eberl, S
Fulham, MJ
Feng, DD
Keywords: Algorithms
Alzheimer Disease
Diagnosis, Differential
Fluorodeoxyglucose F18
Image Enhancement
Image Interpretation, Computer-Assisted
Positron-Emission Tomography
Principal Component Analysis
Reproducibility of Results
Sensitivity and Specificity
Issue Date: 2008
Publisher: IEEE
Source: Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society : personalized healthcare through technology : August 20-24, 2008, Vancouver, British Columbia, Canada, p. 4812-4815 How to cite?
Abstract: Parametric FDG-PET data offer the potential for an automated identification of the different dementia syndromes. Principal component analysis (PCA) can be used for feature extraction in FDG-PET. However, standard PCA is not always successful in delineating the features that have the best discrimination ability. We report a genetic algorithm-based method to identify an optimal combination of eigenvectors so that the resultant features are capable of successfully separating patients with suspected Alzheimer's disease and frontotemporal dementia from normal controls. We compared our approach with standard PCA on a set of 210 clinical cases and improved the performance in separating the dementia types with an accuracy of 90.0% and a Kappa statistic of 0.849. There was very good agreement between the automated technique and the diagnosis given by clinicians.
ISBN: 978-1-4244-1815-2
DOI: 10.1109/IEMBS.2008.4650290
Rights: © 2008 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
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