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|Title:||Optimized acquisition time and image sampling for dynamic SPECT of Tl-201|
Optimum image sampling schedule
Tl-201 tracer kinetics
|Source:||IEEE transactions on medical imaging, June 1998, v. 17, no. 3, p. 334-343 How to cite?|
|Journal:||IEEE transactions on medical imaging|
|Abstract:||With the recent development in scatter and attenuation correction algorithms, dynamic single photon emission computerized tomography (SPECT) can potentially yield physiological parameters, with tracers exhibiting suitable kinetics such as thallium-201 (Tl-201). A systematic way is proposed to investigate the minimum data acquisition times and sampling requirements for estimating physiological parameters with quantitative dynamic SPECT.|
Two different sampling schemes were investigated with Monte Carlo simulations: 1) Continuous data collection for total study duration ranging from 30–240 min. 2) Continuous data collection for first 10–45 min followed by a delayed study at approximately 3 h. Tissue time activity curves with realistic noise were generated from a mean plasma time activity curve and rate constants (K₁- k₄) derived from Tl-201 kinetic studies in 16 dogs. Full dynamic sampling schedules (DynSS) were compared to optimum sampling schedules (OSS).
We found that OSS can reliably estimate the blood flow related K₁ and V[sub d] comparable to DynSS. A 30-min continuous collection was sufficient if only K₁ was of interest. A split session schedule of a 30-min dynamic followed by a static study at 3 h allowed reliable estimation of both K₁ and V[sub d] avoiding the need for a prolonged (>60-min) continuous dynamic acquisition. The methodology developed should also be applicable to optimizing sampling schedules for other SPECT tracers.
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