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Title: Noninvasive quantification of the differential portal and arterial contribution to the liver blood supply front PET measurements using the ¹¹C-acetate kinetic model
Authors: Chen, S
Feng, DD
Keywords: Dual-input function
Noninvasive measurement
Parameter estimation
Positron emission tomography (PET)
Tracer kinetic modeling
Issue Date: Sep-2004
Publisher: Institute of Electrical and Electronics Engineers
Source: IEEE transactions on biomedical engineering, Sept. 2004, v. 51, no. 9, p. 1579-1585 How to cite?
Journal: IEEE transactions on biomedical engineering 
Abstract: Our recent research has demonstrated that ¹¹C-acetate could be a complementary tracer to [sup 18]F-fluorodeoxyglucose (FDG) in positron emission tomography (PET) imaging of hepatocellular carcinoma (HCC). In our previous modeling study, a three-compartment four-parameter model with a fixed contribution ratio of the liver's two blood supplies was proposed to characterize the kinetic behavior of ¹¹C-acetate in liver. However, in real pathology, both tumor and nontumor liver tissue can be heterogeneous in the distribution and proportion of the two blood supplies. To further improve the accuracy of quantitative analysis, the actual proportion of the hepatic artery and portal vein (PV) in different regions of interest (ROIs) was investigated in this study. An extra parameter a[sub v] was included in the model input function to describe the contribution of PV to the liver. Ten ROIs extracted from six patients were used to test the models with fixed/nonfixed weighted dual-input function. The weighted nonlinear least squares algorithm was used to estimate all of the parameters. Evaluation of the adequacy of the two models was conducted and the computer simulation was performed to test the estimation accuracy of the new model. The forward clearance K was also estimated by the linear Patlak method. The results show that the model with parameter a[sub v] in the input function was more suitable for mapping the tracer time activity curves. Moreover, the estimated a[sub v] value fits the practical physiological and pathological conditions well and could be a potential candidate to provide useful additional diagnostic information for the early detection of hepatic metastases.
ISSN: 0018-9294
EISSN: 1558-2531
DOI: 10.1109/TBME.2004.828032
Rights: © 2004 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
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