Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/14968
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Title: Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma
Authors: Yuan, C
Yip, SP 
Wu, VWC 
Kwong, DLW
Cheuk, IWY
Ying, M 
Issue Date: 2015
Source: Radiation oncology, 2015, v. 10, 39, p. 1-7
Abstract: Background: Radiotherapy (RT) of the neck is commonly given to nasopharyngeal carcinoma (NPC) patients for preventing cervical lymph node metastasis. However, neck RT may induce the development of carotid atherosclerosis. The mechanisms of radiation-induced carotid atherosclerosis are still unclear and no previous study has investigated the genetic involvement of radiation-induced carotid atherosclerosis. The present study aims to determine the association between genetic polymorphisms and carotid atherosclerosis in patients treated with RT for nasopharyngeal carcinoma. Methods: The present study recruited 128 post-RT NPC patients. Carotid plaque score was assessed using ultrasonography. Thirteen single nucleotide polymorphisms (SNPs) that affect the function of anti-atherosclerotic genes, including SOD2, SOD3, CAT, PON1, PPARG, ADIPOQ, IL10, TGFB1 and NOS3, were genotyped. Association between the 13 SNPs and carotid atherosclerosis was evaluated using multiple regression after adjustment for covariates (PLINK). Multiple testing was corrected using Benjamini-Hochberg step-up false discovery rate controlling procedure. Results: rs662 and rs705379 of PON1 were close to be significantly associated with carotid plaque score (Corrected P value, P cor = .0528 and Pcor = .0842). When the two SNPs were combined together, TC haplotype in rs662-rs705379 of PON1 was significantly associated with higher carotid plaque score (Pcor < 0.05). None of the other SNPs showed significant association with carotid plaque score. Conclusions: TC haplotype in rs662-rs705379 of PON1 is likely to be a genetic risk factor of carotid plaque score. Post-RT NPC patients with the TC haplotype may need earlier and more frequent carotid ultrasound examinations for early detection of carotid atherosclerosis.
Keywords: Carotid atherosclerosis
Carotid plaque score
Nasopharyngeal carcinoma
Paraoxonase
Radiation
Single nucleotide polymorphisms
Publisher: BioMed Central Ltd.
Journal: Radiation Oncology 
ISSN: 1748-717X
DOI: 10.1186/s13014-015-0341-8
Rights: © 2015 Yuan et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public DomainDedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article,unless otherwise stated.
The following publication Yuan, C., Yip, S. P., Wu, V. W. C., Kwong, D. L. W., Cheuk, I. W. Y., & Ying, M. (2015). Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma. Radiation Oncology, 10, 39, 1-7 is available at https://dx.doi.org/10.1186/s13014-015-0341-8
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