Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12536
Title: Sign-dependent changes in retinal electrical activity with positive and negative defocus in the human eye
Authors: Ho, WC
Wong, OY
Chan, YC
Wong, SW
Kee, CS 
Chan, HHL 
Keywords: Global flash
Multifocal electroretinogram (mfERG)
Neural activity
Optical defocus
Issue Date: 2012
Publisher: Pergamon Press
Source: Vision research, 2012, v. 52, no. 1, p. 47-53 How to cite?
Journal: Vision research 
Abstract: The purpose of this study was to investigate the effect of optical defocus on changes of electrical response as a function of retinal region. Twenty-three subjects (aged 19-25. year) with normal ocular health were recruited for global flash multifocal electroretinogram (mfERG) recordings under control (fully corrected) condition, and short-term positive defocus (+2D and +4D) and negative defocus (-2D and -4D) conditions. The amplitudes and implicit times of direct (DC) and induced (IC) components of mfERG responses were pooled into six concentric rings for analyses. The mfERG responses demonstrated more significant changes in amplitude in paracentral retinal regions than in the central regions under defocused conditions. The paracentral DC amplitude showed a significant reduction under negative defocus conditions. In contrast, the paracentral IC amplitude showed a significant increment under positive defocus conditions. Interestingly, the central IC response showed significant reduction in amplitude only to negative defocus, while increasing its amplitude to positive defocus. However, the DC and IC implicit times were virtually unaffected under defocused conditions. Our findings suggest that human retina is able to differentiate defocused signals and to identify positive and negative defocus. It shows that paracentral retina reacts more vigorously to optical defocus than does central retina.
URI: http://hdl.handle.net/10397/12536
ISSN: 0042-6989
DOI: 10.1016/j.visres.2011.10.017
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