Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12536
PIRA download icon_1.1View/Download Full Text
Title: Sign-dependent changes in retinal electrical activity with positive and negative defocus in the human eye
Authors: Ho, WC
Wong, OY
Chan, YC
Wong, SW
Kee, CS 
Chan, HHL 
Issue Date: 1-Jan-2012
Source: Vision research, 1 Jan. 2012, v. 52, no. 1, p. 47-53
Abstract: The purpose of this study was to investigate the effect of optical defocus on changes of electrical response as a function of retinal region. Twenty-three subjects (aged 19-25. year) with normal ocular health were recruited for global flash multifocal electroretinogram (mfERG) recordings under control (fully corrected) condition, and short-term positive defocus (+2D and +4D) and negative defocus (-2D and -4D) conditions. The amplitudes and implicit times of direct (DC) and induced (IC) components of mfERG responses were pooled into six concentric rings for analyses. The mfERG responses demonstrated more significant changes in amplitude in paracentral retinal regions than in the central regions under defocused conditions. The paracentral DC amplitude showed a significant reduction under negative defocus conditions. In contrast, the paracentral IC amplitude showed a significant increment under positive defocus conditions. Interestingly, the central IC response showed significant reduction in amplitude only to negative defocus, while increasing its amplitude to positive defocus. However, the DC and IC implicit times were virtually unaffected under defocused conditions. Our findings suggest that human retina is able to differentiate defocused signals and to identify positive and negative defocus. It shows that paracentral retina reacts more vigorously to optical defocus than does central retina.
Keywords: Global flash
Multifocal electroretinogram (mfERG)
Neural activity
Optical defocus
Publisher: Pergamon Press
Journal: Vision research 
ISSN: 0042-6989
DOI: 10.1016/j.visres.2011.10.017
Rights: © 2011 Elsevier Ltd. All rights reserved.
© 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
a0780-n04_1628.pdfPre-Published version1.05 MBAdobe PDFView/Open
Open Access Information
Status open access
File Version Final Accepted Manuscript
Access
View full-text via PolyU eLinks SFX Query
Show full item record

Page views

118
Last Week
0
Last month
Citations as of Mar 24, 2024

Downloads

44
Citations as of Mar 24, 2024

SCOPUSTM   
Citations

37
Last Week
0
Last month
0
Citations as of Mar 28, 2024

WEB OF SCIENCETM
Citations

37
Last Week
0
Last month
0
Citations as of Mar 28, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.