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| Title: | Profiles of antibiotic resistome risk in diverse water environments | Authors: | Yang, Y Cai, S Mo, C Dong, J Chen, S Wen, Z |
Issue Date: | 2025 | Source: | Communications earth & environment, 2025, v. 6, 158 | Abstract: | The water environment is considered to be a reservoir for antibiotic resistant bacteria and antibiotic resistance genes. However, profiles of antibiotic resistome risk in different water environments remain largely underexplored. Here we found that the number, abundance and risk of antibiotic resistance genes in wastewater, especially slaughterhouse wastewater, were higher than those in natural water. Then, 6167 high-quality metagenome-assembled genomes were obtained. The main hosts were Escherichia, Desulfobacter, Citrobacter and Pseudomonas_E, respectively. Moreover, distinct of patterns of horizontal gene transfer were observed in different microbes. Overall, microbial composition and resistance risk varied in different water environments and there was a correlation between microbial composition and resistome risk. Therefore, models based on microbial composition were constructed with an accuracy of 86.87 ± 1.18% for predicting the risk of resistance in unknown water environments, providing an essential reference for dealing with antibiotic-resistant pollution and for water management. | Publisher: | Nature Publishing Group | Journal: | Communications earth & environment | EISSN: | 2662-4435 | DOI: | 10.1038/s43247-025-02139-x | Rights: | Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. © The Author(s) 2025 The following publication Yang, Y., Cai, S., Mo, C. et al. Profiles of antibiotic resistome risk in diverse water environments. Commun Earth Environ 6, 158 (2025) is available at https://doi.org/10.1038/s43247-025-02139-x. |
| Appears in Collections: | Journal/Magazine Article |
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