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Title: A performance analysis of convolutional autoencoder modified WaveGAN architectures for realistic 12 lead electrocardiogram synthesis
Authors: Liu, J
Chui, KT
Lee, LK
Lo, K 
Yang, A
Fong, EKS
Issue Date: 2025
Source: Scientific reports, 2025, v. 15, 36443
Abstract: The burgeoning necessity for copious and diverse electrocardiogram (ECG) datasets for deep learning applications in clinical diagnostics has been impeded by the confidential nature of patient data. Related works have shown the effectiveness of additional data generation in enhancing the deep learning models’ performance. This research study introduces a novel Convolutional Autoencoder-WaveGAN (CAE-WaveGAN) technique for generating synthetic but realistic 12-lead ECG images to address data scarcity. The proposed model leverages a convolutional autoencoder for efficient feature extraction from ECG signals, which is then utilized by a WaveGAN generator to synthesize high-fidelity ECG images. The method provides a practical solution for expanding ECG training datasets where patient privacy constraints and data scarcity limit the development of robust deep learning models for cardiovascular diagnosis. We conducted a comprehensive performance analysis of various CAE-WaveGAN configurations through an ablation study on the CODE-15% dataset. Experimental results demonstrate that CAE-WaveGAN achieves superior performance across all evaluation metrics, with 19.8% improvement in PSNR and 59.3% enhancement in SSIM compared to baseline methods. Our findings from the ablation study reveal that the optimal CAE-WaveGAN architecture significantly surpasses the traditional WaveGAN in terms of stability and loss metrics, offering a promising solution for generating realistic ECG data in clinical machine learning applications.
Keywords: 12-Lead ECG synthesis
Convolutional autoencoder
Deep learning
ECG data generation
Feature extraction
Generative adversarial networks
Publisher: Nature Publishing Group
Journal: Scientific reports 
EISSN: 2045-2322
DOI: 10.1038/s41598-025-20470-3
Rights: Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
© The Author(s) 2025
The following publication Liu, J., Chui, K.T., Lee, LK. et al. A performance analysis of convolutional autoencoder modified WaveGAN architectures for realistic 12 lead electrocardiogram synthesis. Sci Rep 15, 36443 (2025) is available at https://doi.org/10.1038/s41598-025-20470-3.
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