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Title: | An analysis of chemical ingredients network of Chinese herbal formulae for the treatment of coronary heart disease | Authors: | Ding, F Zhang, Q Ung, COL Wang, Y Han, Y Hu, Y Qi, J |
Issue Date: | 2015 | Source: | PLoS one, 2015, v. 10, no. 2, 116441 | Abstract: | As a complex system, the complicated interactions between chemical ingredients, as well as the potential rules of interactive associations among chemical ingredients of traditional Chinese herbal formulae are not yet fully understood by modern science. On the other hand, network analysis is emerging as a powerful approach focusing on processing complex interactive data. By employing network approach in selected Chinese herbal formulae for the treatment of coronary heart disease (CHD), this article aims to construct and analyze chemical ingredients network of herbal formulae, and provide candidate herbs, chemical constituents, and ingredient groups for further investigation. As a result, chemical ingredients network composed of 1588 ingredients from 36 herbs used in 8 core formulae for the treatment of CHD was produced based on combination associations in herbal formulae. In this network, 9 communities with relative dense internal connections are significantly associated with 14 kinds of chemical structures with P<0.001. Moreover, chemical structural fingerprints of network communities were detected, while specific centralities of chemical ingredients indicating different levels of importance in the network were also measured. Finally, several distinct herbs, chemical ingredients, and ingredient groups with essential position in the network or high centrality value are recommended for further pharmacology study in the context of new drug development. | Publisher: | Public Library of Science | Journal: | PLoS one | EISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0116441 | Rights: | © 2015 Ding et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited The following publication: Ding F, Zhang Q, Ung COL, Wang Y, Han Y, Hu Y, et al. (2015) An Analysis of Chemical Ingredients Network of Chinese Herbal Formulae for the Treatment of Coronary Heart Disease. PLoS ONE 10(2): e0116441 is available at https://doi.org/10.1371/journal.pone.0116441 |
Appears in Collections: | Journal/Magazine Article |
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