Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/106064
Title: | Increased prefrontal activation during verbal fluency task after repetitive transcranial magnetic stimulation treatment in depression : a functional near-infrared spectroscopy study | Authors: | Huang, J Zhang, J Zhang, T Wang, P Zheng, Z |
Issue Date: | 4-Apr-2022 | Source: | Frontiers in psychiatry, 4 Apr. 2022, v. 13, 876136 | Abstract: | Background: Previous studies have shown the clinical effect of 2 Hz repetitive transcranial magnetic stimulation (rTMS) for depression; however, its underlying neural mechanisms are poorly understood. The aim of this study was to examine the effects of rTMS on the activity of the prefrontal cortex in patients with depression, using functional near-infrared spectroscopy (fNIRS). Methods: Forty patients with major depressive disorder (MDD) and 40 healthy controls were enrolled in this study. Patients underwent 4 weeks of 2 Hz TMS delivered to the right dorsolateral prefrontal cortex (DLPFC). fNIRS was used to measure the changes in the concentration of oxygenated hemoglobin ([oxy-Hb]) in the prefrontal cortex during a verbal fluency task (VFT) in depressed patients before and after rTMS treatment. The severity of depression was assessed using the Hamilton Rating Scale for Depression-24 item (HAMD-24). Results: Prior to rTMS, depressed patients exhibited significantly smaller [oxy-Hb] values in the bilateral prefrontal cortex during the VFT compared with the healthy controls. After 4 weeks of 2 Hz right DLPFC rTMS treatment, increased [oxy-Hb] values in the bilateral frontopolar prefrontal cortex (FPPFC), ventrolateral prefrontal cortex (VLPFC) and left DLPFC during the VFT were observed in depressed patients. The increased [oxy-Hb] values from baseline to post-treatment in the right VLPFC in depressed patients were positively related to the reduction of HAMD score following rTMS. Conclusion: These findings suggest that the function of the prefrontal cortex in depressed patients was impaired and could be recovered by 2 Hz rTMS. The fNIRS-measured prefrontal activation during a cognitive task is a potential biomarker for monitoring depressed patients’ treatment response to rTMS. Copyright |
Keywords: | Functional near-infrared spectroscopy Major depressive disorder Prefrontal cortex Repetitive transcranial magnetic stimulation Verbal fluency task |
Publisher: | Frontiers Research Foundation | Journal: | Frontiers in psychiatry | EISSN: | 1664-0640 | DOI: | 10.3389/fpsyt.2022.876136 | Rights: | Copyright © 2022 Huang, Zhang, Zhang, Wang and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)(https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided
the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The following publication Huang J, Zhang J, Zhang T, Wang P and Zheng Z (2022) Increased Prefrontal Activation During Verbal Fluency Task After Repetitive Transcranial Magnetic Stimulation Treatment in Depression: A Functional Near-Infrared Spectroscopy Study. Front. Psychiatry 13:876136. is available at https://doi.org/10.3389/fpsyt.2022.876136. |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
fpsyt-13-876136.pdf | 4.09 MB | Adobe PDF | View/Open |
Page views
5
Citations as of May 12, 2024
Downloads
1
Citations as of May 12, 2024
SCOPUSTM
Citations
7
Citations as of May 17, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.