Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/10246
Title: Diterpenoid tanshinones and phenolic acids from cultured hairy roots of salvia miltiorrhiza bunge and their antimicrobial activities
Authors: Zhao, J
Lou, J
Mou, Y
Li, P
Wu, J 
Zhou, L
Keywords: Antimicrobial activity
Cultured hairy roots
Diterpenoid tanshinones
Phenolic acids
Salvia miltiorrhiza Bunge
Issue Date: 2011
Publisher: Mdpi Ag
Source: Molecules, 2011, v. 16, no. 3, p. 2259-2267 How to cite?
Journal: Molecules 
Abstract: Four diterpenoid tanshinones and three phenolic acids were isolated from the crude ethanol extract of the cultured hairy roots of Salvia miltiorrhiza Bunge by bioassayguided fractionation. By means of physicochemical and spectrometric analysis, they were identified as tanshinone IIA (1), tanshinone I (2), cryptotanshinone (3), dihydrotanshinone I (4), rosmarinic acid (5), caffeic acid (6), and danshensu (7). These compounds were evaluated to show a broad antimicrobial spectrum of activity on test microorganisms including eight bacterial and one fungal species. Among the four tanshinones, cryptotanshinone (3) and dihydrotanshinone I (4) exhibited stronger antimicrobial activity than tanshinone IIA (1) and tanshinone I (2). The results indicated that the major portion of the antimicrobial activity was due to the presence of tanshinones and phenolic acids in S. miltiorrhiza hairy roots, which could be used as the materials for producing antimicrobial agents for use in agricultural practice in the future.
URI: http://hdl.handle.net/10397/10246
DOI: 10.3390/molecules16032259
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