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Title: Systematic review and meta-analysis of randomised controlled trials for evaluating the effectiveness of virtual reality therapy for social anxiety disorder
Authors: Wong, KP 
Lai, CYY 
Qin, J 
Wong, KP 
Lai, CYY 
Qin, J 
Issue Date: Jul-2023
Source: Journal of affective disorders, 15 July 2023, v. 333, p. 353-364
Abstract: Objective: To evaluate the effectiveness of VR therapy (VRT) for symptoms related to social anxiety disorder (SAD), namely fear and avoidance of social interactions and performance situations (FASIP), fear of negative evaluation (FNE), anxiety and depression, a systematic review and meta-analysis were performed. Methods: Medline, PubMed, Science Direct, Web of Science, CINAHL, PsychINFO and Scopus were searched to include randomised controlled trials of VRT for SAD that met the criteria. A total of 15 RCTs with 720 participants published between 1998 and 2022 were included. Hedge's g with a 95 % confidence interval (CI) was adopted to compute the effect sizes. Results: Results showed no difference between the effect of VRT and cognitive behavioural therapy (CBT) on FASIP, FNE, anxiety and depression and a large effect size for VRT versus the waitlist control group on FASIP (g = −1.170, 95 % CI: −2.056–0.283; p < 0.010). The moderator analysis demonstrated that VRT was superior to the controlled group in addressing FASIP, FNE and anxiety when the sample size was smaller than 50 and the number of sessions was five or fewer. Limitations: Differences in hardware, software and intervention duration for VRT across studies. Conclusion: This study confirmed the feasibility of VRT in alleviating the FASIP in patients with SAD, with the waitlist control group as a comparison. However, the effectiveness of VRT was not significant in FASIP, FNE, anxiety and depression compared to CBT. Additional social interaction scenarios should be developed in VRT, standardised hardware should be used and the proper length of exposure time to VR should be determined to enhance the efficacy of VRT.
Keywords: Depression
Fear of negative evaluation
Fear of social interactions
Randomised controlled trials
Social anxiety disorder
Virtual reality therapy
Publisher: Elsevier BV
Journal: Journal of affective disorders 
ISSN: 0165-0327
EISSN: 1573-2517
DOI: 10.1016/j.jad.2023.04.043
Rights: © 2023 Elsevier B.V. All rights reserved.
© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
The following publication Wong, K. P., et al. (2023). "Systematic review and meta-analysis of randomised controlled trials for evaluating the effectiveness of virtual reality therapy for social anxiety disorder." Journal of Affective Disorders 333: 353-364 is available at https://doi.org/10.1016/j.jad.2023.04.043.
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