Shape memory composite bone nail and preparation, using method and application thereof

Abstract

The invention relates to the technical field of bone tissue repair, and particularly discloses a shape memory composite bone nail and preparation, a using method and application thereof. The shape memory composite bone nail comprises the following raw material components in percentages by mass: 1.8-2.2% of hydroxyapatite, 0.5-1.5% of RGD tripeptide and 96.5-97.5% of polyurethane. The polyurethane is prepared from the following raw material components by reaction based on 100% of the polyurethane by mass: 55.0-57.0% of diphenylmethane diisocyanate, 14.0-16.0% of a chain extender and 28.0-30.0% of polycaprolactone glycol. The shape memory composite bone nail has a shape memory function, a self-regulated mechanical property and a tissue growth function; the hydroxyapatite does not affect the shape memory function, but also has good biological compatibility and histocompatibility, and is suitable for the field of repair of bone tissues. 本发明涉及骨组织修复技术领域，具体公开一种形状记忆复合骨钉及其制备、使用方法和应用。所述形状记忆复合骨钉包括质量百分比如下的原料组分：羟基磷灰石1.8％～2.2％；RGD三肽0.5％～1.5％；聚氨酯96.5％～97.5％；其中，以所述聚氨酯质量100％计，包括如下的原料组分经过反应而成：二苯基甲烷二异氰酸酯55.0％～57.0％；扩链剂14.0％～16.0％；聚己内酯二醇28.0％～30.0％。本发明形状记忆复合骨钉具有形状记忆功能、自调节机械性能和组织生长的功能，羟基磷灰石不仅不会影响形状记忆功能而且还具有良好生物相容性和组织相容性，适用于骨组织的修复领域中。