Bufalin micelle nano-preparation and preparation method thereof

Abstract

The invention provides a bufalin micelle nano-preparation. The bufalin micelle nano-preparation comprises bufalin, and a lipidized polypeptide micelle carrier which wraps the bufalin, and one molecule of the lipidized polypeptide micelle carrier comprises one molecule of a hydrophilic unit and one molecule of a hydrophobic unit connected with the hydrophilic unit, wherein the hydrophilic unit is an asymmetric dendritic polypeptide polymer unit, the hydrophobic unit is a lipid unit, and the end of the dendritic polypeptide polymer unit carries a positive charge. 本发明提供了一种蟾毒灵胶束纳米制剂，包括蟾毒灵、以及包裹所述蟾毒灵的脂化多肽胶束载体，且一分子的所述脂化多肽胶束载体包括一分子亲水单元和一分子与所述亲水单元相连的疏水单元，其中，所述亲水单元为不对称的树状多肽聚合物单元，所述疏水单元为脂质单元，且所述树状多肽聚合物单元的末端携带正电荷。