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Title: Video-rate dual-modal wide-beam harmonic ultrasound and photoacoustic computed tomography
Authors: Zhang, Y 
Wang, Y
Lai, P 
Wang, L
Issue Date: Mar-2022
Source: IEEE transactions on medical imaging, Mar. 2022, v. 41, no. 3, p. 727-736
Abstract: Dual-modal ultrasound (US) and photoacoustic (PA) imaging has tremendous advantages in biomedical applications, such as pharmacokinetics, cancer screening, and imaging-guided therapy. Compared with ring-shaped arrays, a linear piezoelectric transducer array applies to more anatomical sites and has been widely used in US/PA imaging. However, the linear array may limit the imaging quality due to narrow bandwidth, partial detection view, or sparse spatial sampling. To meet clinic demand of high-quality US/PA imaging with the linear transducer, we develop dual-modal wide-beam harmonic ultrasound (WBHUS) and photoacoustic computed tomography at video rate. The harmonic US imaging employs pulse phase inversion to reduce clutters and improve spatial resolution. Wide-beam US transmission can shorten the scanning times by 267% and enables a 20-Hz imaging rate, which can minimize motion artifacts in in vivo imaging. The harmonic US imaging does not only provide accurate anatomical references for locating PA features but also reduces artifacts in PA images. The improved image quality allows us to acquire high-resolution anatomical structures in deep tissue without labeling. The fast-imaging speed enables visualizing interventional procedures and monitoring the pulsations of the thoracic aorta and radial artery in real-time. The video-rate dual-modal harmonic US and single-shot PA computed tomography use a clinical-grade linear-array transducer and thus can be readily implemented in clinical US imaging.
Keywords: Harmonic ultrasound imaging
High speed
Linear-array ultrasound transducer
Photoacoustic imaging
Wide-beam transmission
Publisher: Institute of Electrical and Electronics Engineers
Journal: IEEE transactions on medical imaging 
ISSN: 0278-0062
EISSN: 1558-254X
DOI: 10.1109/TMI.2021.3122240
Rights: © 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
The following publication Y. Zhang, Y. Wang, P. Lai and L. Wang, "Video-Rate Dual-Modal Wide-Beam Harmonic Ultrasound and Photoacoustic Computed Tomography," in IEEE Transactions on Medical Imaging, vol. 41, no. 3, pp. 727-736, March 2022 is available at https://dx.doi.org/10.1109/TMI.2021.3122240.
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