Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/91245
DC Field | Value | Language |
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dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.creator | Zhu, X | en_US |
dc.creator | Chen, Y | en_US |
dc.creator | Chan, THW | en_US |
dc.creator | Chow, MC | en_US |
dc.date.accessioned | 2021-10-18T06:34:27Z | - |
dc.date.available | 2021-10-18T06:34:27Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/91245 | - |
dc.language.iso | en | en_US |
dc.rights | Assignee: The Hong Kong Polytechnic University | en_US |
dc.rights | Assignee: The Royal Institution for the Advancement of Learning/McGill University | en_US |
dc.title | Peptides for specific inhibition of Jag 1-Notch 1 pathway | en_US |
dc.type | Patent | en_US |
dc.description.otherinformation | US11117932; US11117932 B2; US11117932B2; US11,117,932; US11,117,932 B2; 11117932; Appl. No. 17/261,573 | en_US |
dcterms.abstract | Aberrant cross talk between Notch ligand (e.g. Jag1) and Notch receptor (e.g. Notch1) has been implicated in tumorigenesis in the colon. Inhibition of Notch pathway is therefore an attractive approach for treating diseases with upregulated Jag1 e.g. colorectal cancer (CRC). Pan-notch inhibitors like gamma secretase inhibitors (GSIs) have been developed to inhibit Notch and its downstream events. However, severe gastrointestinal toxicity profiles impede the clinical development of GSIs. The present invention develops novel oligopeptides that specifically inhibit Jag1-Notch1 pathway without interfering DLL1-Notch1 or DLL4-Notch1, which demonstrates a clear advantage over pan-notch inhibitors. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | US Patent 11,117,932 B2. Washington, DC: US Patent and Trademark Office, 2021. | en_US |
dcterms.issued | 2021-09-14 | - |
dc.description.country | US | - |
dc.description.validate | 202110 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
Appears in Collections: | Patent |
Files in This Item:
File | Description | Size | Format | |
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us11117932b2.pdf | 1.84 MB | Adobe PDF | View/Open |
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