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dc.contributorDepartment of Applied Biology and Chemical Technologyen_US
dc.creatorZhu, Xen_US
dc.creatorChen, Yen_US
dc.creatorChan, THWen_US
dc.creatorChow, MCen_US
dc.rightsAssignee: The Hong Kong Polytechnic Universityen_US
dc.rightsAssignee: The Royal Institution for the Advancement of Learning/McGill Universityen_US
dc.titlePeptides for specific inhibition of Jag 1-Notch 1 pathwayen_US
dc.description.otherinformationUS11117932; US11117932 B2; US11117932B2; US11,117,932; US11,117,932 B2; 11117932; Appl. No. 17/261,573en_US
dcterms.abstractAberrant cross talk between Notch ligand (e.g. Jag1) and Notch receptor (e.g. Notch1) has been implicated in tumorigenesis in the colon. Inhibition of Notch pathway is therefore an attractive approach for treating diseases with upregulated Jag1 e.g. colorectal cancer (CRC). Pan-notch inhibitors like gamma secretase inhibitors (GSIs) have been developed to inhibit Notch and its downstream events. However, severe gastrointestinal toxicity profiles impede the clinical development of GSIs. The present invention develops novel oligopeptides that specifically inhibit Jag1-Notch1 pathway without interfering DLL1-Notch1 or DLL4-Notch1, which demonstrates a clear advantage over pan-notch inhibitors.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationUS Patent 11,117,932 B2. Washington, DC: US Patent and Trademark Office, 2021.en_US
dc.description.validate202110 bcrcen_US
dc.description.oaVersion of Recorden_US
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