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Title: Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation
Authors: Zhao, Y 
Wu, S 
Yang, W 
He, Y 
Li, X 
Qiu, X 
Issue Date: 14-Apr-2020
Source: US Patent 10,618,939 B2. Washington, DC: US Patent and Trademark Office, 2020.
Abstract: The present invention relates to a Beclin 1-UVRAG complex structure which reveals a tightly packed coiled coil assembly with Beclin 1 and UVRAG residues complementing each other to form a stable dimeric complex. This potent physical interaction is critical for UVRAG-dependent EGFR degradation but less critical for autophagy. Targeting the Beclin 1 coiled coil domain with rationally designed stapled peptides leads to enhanced autophagy activity and EGFR degradation in non-small cell lung cancer (NSCLC) cell lines, suggesting translational value for these compounds.
Rights: Assignee: The Hong Kong Polytechnic University.
Appears in Collections:Patent

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