Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/88285
| Title: | Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation | Authors: | Zhao, Y Wu, S Yang, W He, Y Li, X Qiu, X |
Issue Date: | 14-Apr-2020 | Source: | US Patent 10,618,939 B2. Washington, DC: US Patent and Trademark Office, 2020. | Abstract: | The present invention relates to a Beclin 1-UVRAG complex structure which reveals a tightly packed coiled coil assembly with Beclin 1 and UVRAG residues complementing each other to form a stable dimeric complex. This potent physical interaction is critical for UVRAG-dependent EGFR degradation but less critical for autophagy. Targeting the Beclin 1 coiled coil domain with rationally designed stapled peptides leads to enhanced autophagy activity and EGFR degradation in non-small cell lung cancer (NSCLC) cell lines, suggesting translational value for these compounds. | Rights: | Assignee: The Hong Kong Polytechnic University. |
| Appears in Collections: | Patent |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| us10618939b2.pdf | 1.7 MB | Adobe PDF | View/Open |
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