Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/87062
DC FieldValueLanguage
dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorTo, Sheung Chun-
dc.identifier.urihttps://theses.lib.polyu.edu.hk/handle/200/7748-
dc.language.isoEnglish-
dc.titleExploration and development of carbazole-based phosphine ligands towards Suzuki-Miyaura cross-coupling and Buchwald-Hartwig amination-
dc.typeThesis-
dcterms.abstractThe research study is focused on the design and synthesis of bulky heterocyclic phosphine ligands. An easily accessible synthesis of a new family of carbazolyl-derived phosphine ligands has been investigated. The substituted carbazoles are synthesized by employing the Fischer indolisation protocol and followed by reduction using Palladium/Charcoal. This carbazole is coupled with iodobromobenzene by ligand-free copper catalyzed C-N bond formation. The ligand scaffold can be made easily without tedious chromatographic purification. The exploration of palladium-catalyzed cross-coupling using carbazole-based phosphine ligands has been demonstrated. With the combination of phosphine ligand and Pd(OAc)₂, a difficult tri-ortho-substituted biaryl synthesis is accomplished. In particular, the catalyst loading down to 0.02 mol% of Pd for non-activated aryl chloride coupling can be achieved. Also, this catalyst system is demonstrated to be effective in low catalyst loading amination of aryl chlorides. The catalyst loading could reach 0.05 mol% Pd in the coupling of 2-chlorotoluene and N-methylaniline.-
dcterms.accessRightsopen access-
dcterms.educationLevelM.Phil.-
dcterms.extent269 pages : illustrations ; 30 cm-
dcterms.issued2014-
dcterms.LCSHLigands (Biochemistry)-
dcterms.LCSHPhosphorus compounds.-
dcterms.LCSHCatalysis.-
dcterms.LCSHHong Kong Polytechnic University -- Dissertations-
Appears in Collections:Thesis
Show simple item record

Page views

7
Citations as of Jul 3, 2022

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.