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Title: Responsive lanthanide complexes for recognition of bio-species
Authors: Yip, Yuk Wang
Degree: Ph.D.
Issue Date: 2017
Abstract: The development of lanthanide complexes for recognition of various prevalent bio-species, including metal cations and anions, has received great attention. Such senors offer some benefits over conventional sensors: their long-lived luminescence enables time-resolved detection and sharp narrow emission line. The work presented herein is divided into seven chapters, the first of which consists of a review of the general background, coordination properties and photophysical properties of lanthanides, along with a discussion of the classification of sensors, their signal transduction mechanisms and strategies on the designs of responsive lanthanide sensors. 1,4,7,10-tetraazacyclododecane and its derivatives, which are the marcrocyclic metal chelators, are recognized as a promising chelator for formation of highly stable complexes. To aid the development of stable lanthanide probes, a synthesis of a series of marcrocyclic derivatives has been executed and described in Chapter Two. Chapter Three focuses on the synthesis and evaluation of new water-soluble europium(III) complexes for selective detection of hydrogen sulfide among other inorganic and organic sulphur compounds. In the binding of copper(II) ion, its luminescence is almost completely quenched but is recovered upon addition of hydrogen sulfide. Such alternate addition of copper(II) ion-hydrogen sulfide demonstrates an on-off-on type of luminescence, which allows it to be utilized as a monitoring system. Chapter Four describes the synthesis and investigation of new reaction-based europium(III) complexes for selective detection of cysteine among other thiol derivatives and amino acids. A range of luminescence and kinetic studies have been performed to evaluate the photophysical properties, pH behavior, kinetic parameters and confirmation of reaction mechanisms. A series of europium(III) complexes bearing dipicolylamine as a receptor have been developed for selective detection of Zinc and this is shown in Chapter Five. Detailed luminescence studies have been carried out to investigate their photophycal properties, binding stoichiometry of a binding event and binding constants. In the binding of Zinc, EuL5 exhibits selective response towards ATP over ADP and AMP and its binding study has also been performed. Chapter Six presents work on the development of a series of copper(I) responsive probes. Through a series of titrations with various cations, the selectivity of the probes is assessed. Their photophysical studies have also been performed. Chapter Seven describes the experimental procedures for the synthesis and general experimental procedures. The complexes described in this dissertation demonstrate great promise in the detection of bio-species of interest.
Subjects: Hong Kong Polytechnic University -- Dissertations
Rare earth metals
Pages: 299 pages : color illustrations
Appears in Collections:Thesis

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