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Title: Multi-functional thermoresponsive hydrogel and application on textile for skin and wound care
Authors: Wang, Xiaowen
Degree: Ph.D.
Issue Date: 2017
Abstract: The thesis presented a general and effective route to the synthesis of thermoresponsive hydrogels based on poly(ethylene glycol)-poly(e-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG), as well as the antibacterial modification of the PEG-PCL-PEG block copolymers through quaternization using quaternary ammonium salts (QAS). The study subsequently made use of the synthesized functional hydrogels for the fabrication of smart textile-based materials by a simple coating method, which can be used as a functional complex dressing for skin and wound care. The study primarily includes three research systems: (i) Design, synthesis and characterization of PEG-PCL-PEG hydrogel through coupling PEG and PCL with a chemical linker hexamethylene diisocyanate (HMDI) The as-obtained amphiphilic block copolymers-based hydrogel had non-cytotoxicity and showed a thermosemsitive sol-gel-sol transition behavior. The chemical structure of the synthesized block copolymers was confirmed by FTIR and 1H-NMR spectra. The surface morphology, the mechanism of the sol-gel transition behavior, and the in vitro drug release performance of the thermoresponsive hydrogel were investigated in detail through various characterization analyses. (ii) Synthesis, characterization and evaluation of a PEG-PCL-QAS-PCL-PEG antibacterial hydrogel with QAS as an antibacterial modification agent
Biomaterials are readily infected with microorganisms, thus posing a serious threat to the human health care. The study was extended to the antibacterial modification of PEG-PCL-PEG copolymer with an inexpensive and commercial quaternary ammonium salt, namely bis(2-hydroxyethyl) methylammonium chloride (DMA), as an antibacterial modification agent. The effective synthesis of the antibacterial copolymer PEG-PCL-DMA-PCL-PEG was well confirmed by FTIR and 1H-NMR spectra. At an appropriate level, the modification of the copolymer PEG-PCL-DMA-PCL-PEG by DMA could render efficient antibacterial property to it without altering its fascinating intrinsic properties including the thermosensitivity (e.g. the skin temperature-induced sol-gel transition), non-cytotoxicity, and drug controlled release. A detailed study on the sol-gel-sol transition behavior of different extent modified copolymers showed that an appropriate extent of modification with DMA could lead to the formation of an optimized antibacterial hydrogel. The work presented here will open up an avenue towards synthesis of various antibacterial copolymers with different kinds of blocks other than PEG and PCL using DMA or its analogues as the functional building block. (iii) Fabrication of a smart multi-functional textile-based material for topical skin applications by coating the as-prepared antibacterial thermoresponsive hydrogel onto a nonwoven fabric A functional textile-based hydrogel system has been prepared by a coating method, which can be used as wound dressing for skin and wound care or as a facial mask. It is worth pointing out that the novel moisture & exudate management property was obtained after the effective combination of the prepared thermoresponsive hydrogel with flexible absorbent textile substrates. The sweat, blood and other body fluids can be effectively drained out of the skin in a unidirectional manner (from inside to outside), which shows great significance in keeping the topical skin area clean, comfortable, and appropriate for building a good moist micro-environment. The as-fabricated complex dressing seems to be an ideal dressing material for skin care and wound treatment applications based on its fascinating properties such as biocompatibility, breathability, controlled drug release and moisture management. It will pave the way for development of various polymer-or textile-based functional materials that are applicable in large scale to various industries.
Subjects: Smart materials.
Biomedical materials.
Hong Kong Polytechnic University -- Dissertations
Pages: xv, 175 pages : color illustrations
Appears in Collections:Thesis

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