Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76818
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.contributorInnovation and Technology Development Office-
dc.creatorWan, S-
dc.creatorZhou, M-
dc.creatorYuan, J-
dc.creatorHuang, L-
dc.creatorJiang, T-
dc.creatorLi, X-
dc.creatorZhang, X-
dc.creatorSun, D-
dc.date.accessioned2018-06-13T02:56:22Z-
dc.date.available2018-06-13T02:56:22Z-
dc.identifier.urihttp://hdl.handle.net/10397/76818-
dc.language.isozhen_US
dc.rightsAssignee: 中国海洋大学en_US
dc.rightsAssignee: 香港理工大学en_US
dc.titleChroman and chromene derivatives as tumor multidrug resistance inhibitor as well as preparation method and application of chroman and chromene derivativesen_US
dc.typePatenten_US
dc.description.otherinformationInventor name used in this publication: 万升标en_US
dc.description.otherinformationInventor name used in this publication: 周铭祥en_US
dc.description.otherinformationInventor name used in this publication: 苑建en_US
dc.description.otherinformationInventor name used in this publication: 黄丽琼en_US
dc.description.otherinformationInventor name used in this publication: 江涛en_US
dc.description.otherinformationInventor name used in this publication: 李学敏en_US
dc.description.otherinformationInventor name used in this publication: 张晓瑜en_US
dc.description.otherinformationInventor name used in this publication: 孙东魁en_US
dc.description.otherinformationTitle in Traditional Chinese: 一種抗腫瘤多藥耐藥抑制劑色滿和色烯衍生物及其製備方法和應用en_US
dcterms.abstractThe invention provides chroman and chromene derivatives as tumor multidrug resistance inhibitors as well as a preparation method of the chroman and chromene derivatives. The chroman and chromene derivatives are represented by the following general formulae I and II respectively, wherein R is one or more of hydrogen, hydroxy, alkoxy, alkyl amino, alkyl acylamino, halogen, fluorine-containing alkyl or benzoyl; the benzoyl contains one or more of substituent groups of hydroxy, alkoxy, alkyl amino, alkyl acylamino, halogen or fluorine-containing alkyl; the alkyls in the alkoxy, the alkyl amino, the fluorine-containing alkyl and the alkyl acylamino are linear-chain or branch-chain alkyls with 1-10 carbon atoms; X is hydrogen or oxygen; and Y is oxygen or nitrogen. The chroman and chromene derivatives have low toxicity and good tumor multidrug resistance inhibiting activities, and can be used for preparing drugs for treating breast cancer, colon cancer, prostate cancer, leukemia, myeloma, pancreatic cancer and the like.-
dcterms.abstract本发明提供了一种抗肿瘤多药耐药抑制剂色满和色烯衍生物及其制备方法,分别由下述通式I和通式II表示:通式I和通式II中R为氢、羟基、烷氧基、烷氨基、烷基酰胺基、卤素、含氟烷基或苯甲酰基中的一种或多种,所述苯甲酰基含有羟基、烷氧基、烷氨基、烷基酰胺基、卤素或含氟烷基取代基中的一种或多种,其中烷氧基、烷氨基、含氟烷基、烷基酰胺基中烷基为具有1-10个碳原子的直链或支链的烷基,式中X为氢或氧,式中Y为氧或氮。本发明的色满和色烯衍生物是低毒的且有良好抗肿瘤多药耐药活性,所述色满和色烯衍生物可以用于制备治疗用于治疗乳腺癌、结肠癌、前列腺癌、白血病、骨髓瘤和胰腺癌等的药物。-
dcterms.alternative一种抗肿瘤多药耐药抑制剂色满和色烯衍生物及其制备方法和应用-
dcterms.bibliographicCitation中国专利 ZL 201210045877.3-
dcterms.issued2014-07-02-
dc.description.countryChina-
dc.description.validate201806 bcrc-
dc.description.oaVersion of Recorden_US
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