High polymer-nanoparticle conjugates and method for their stabilization, analysis system and therapeutic agent carrier

Abstract

A method for stabilizing conjugates between macromolecule and nanoparticle by forming a thin reinforcement layer over the surface of a nanoparticle after macromolecule chains have attached to the surface of the nanoparticle. The stabilized conjugates can be used in a wide range of applications such as in vitro diagnostics, in vivo imaging and therapeutics, which need to be conducted under various severe or harsh conditions. 一种使高分子与纳米颗粒间的共轭物稳定的方法，通过在高分子链已经吸附到纳米颗粒表面后在纳米颗粒表面形成薄的加强层来实现。稳定的共轭物可在大范围的应用中使用，例如体外诊断、体内成像和治疗，这些应用需要在各种苛刻条件或严酷条件下进行。