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Title: Daidzein-hydroxypropyl-beta-cyclodextrin clathrate and its preparation method
Other Title: 大豆苷元-羟丙基-β-环糊精包合物及其制备方法
Authors: Li, Y 
Yang, DJ 
Zhou, W
Issue Date: 7-May-2014
Source: 中国专利 ZL 201110102556.8
Abstract: The invention discloses a daidzein-hydroxypropyl-beta-cyclodextrin clathrate and its preparation method. The clathrate comprises hydroxypropyl-beta-cyclodextrin and daidzein, the mol ratio of hydroxypropyl-beta-cyclodextrin and daidzein is 1:1 to 0.1, the preparation method comprises the following steps: fully mixing hydroxypropyl-beta-cyclodextrin and daidzein according to the mol ratio of 1:1 to 0.1, placing in a reaction vessel at the temperature of 50-200 DEG C, then introducing a supercritical CO2 fluid in the reaction vessel, wherein the pressure reach 10 MPa-40 MPa, reacting daidzein and hydroxypropyl-beta-cyclodextrin for 3-24 hours and then rapidly decompressing to obtain the clathrate. The method can substantially increase the solubility of daidzein, the prepared clathrate enables high clathration rate, controllable particle size, good stability, no organic solvent residue and easy administration or injection preparation.
Publisher: 中华人民共和国国家知识产权局
Rights: 专利权人: The Hong Kong Polytechnic University.
Appears in Collections:Patent

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