Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/5764
Title: | (-)-Epigallocatechin gallate derivatives for inhibiting proteasome | Authors: | Chan, TH Lam, WH Chow, LMC Dou, QP Kuhn, DJ Kazi, A Wan, SB Landis-Piwowar, KR |
Issue Date: | 5-Jun-2012 | Source: | US Patent 8,193,377 B2. Washington, DC: US Patent and Trademark Office, 2012. | Abstract: | (-)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (-)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides compounds of generally formulae below, wherein R₁₁, R₁₂, R₁₃, R₂₁, R₂₂, R₂, R₃, and R₄ are each independently selected from the group consisting of --H, and C₁ to C₁₀ acyloxyl group; and R₅ is selected from the group consisting of --H, C₁-C₁₀-alkyl, C₂-C₁₀-alkenyl, C₂-C₁₀-alkynyl, C₃-C₇-cycloalkyl, phenyl, benzyl and C₃-C₇-cycloalkenyl, whereas each of the last mentioned 7 groups can be substituted with any combination of one to six halogen atoms; at least one of R₁₁, R₁₂, R₁₃, R₂₁, R₂₂, R₂, R₃ and R₄ is --H, which were found to be more potent than their non-protected counterparts, which can be used as proteasome inhibitors to reduce tumor cell growth. | Rights: | Assignee: The Hong Kong Polytechnic University. Assignee: Wayne State University. Assignee: University of South Florida. |
Appears in Collections: | Patent |
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us8193377b2.pdf | 2.06 MB | Adobe PDF | View/Open |
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