Depression mouse model as well as construction method and application thereof

Abstract

The invention relates to the technical field of biological medicines, and particularly discloses a depression mouse model as well as a construction method and application thereof. The construction method of the depression mouse model comprises the step of carrying out microglial cell specific Csf1r heterozygous knockout on a mouse. The depression mouse model is obtained by inducing the depression-like behavior of the mouse through microglial specific Csf1r heterozygous knockout, and compared with an existing method for causing the depression-like behavior of the animal through chronic unpredictable mild pressure stimulation, the depression phenotype is stable, the depression phenotype appears quickly, and the depression-like behavior of the animal is not influenced by the depression-like behavior. Repeated experiments of depression related researches are facilitated, and experimental results with high repeatability can be obtained. 本申请涉及生物医药技术领域，具体公开一种抑郁症小鼠模型及其构建方法与应用。其中抑郁症小鼠模型的构建方法包括对小鼠进行小胶质细胞特异性Csf1r杂合敲除。本申请通过小胶质特异性Csf1r杂合敲除诱导小鼠出现抑郁样行为，获得抑郁症小鼠模型，与现有的通过慢性不可预测的轻度压力刺激造成动物抑郁样行为的方法相比较，抑郁的表型稳定且抑郁表型出现快，便于进行抑郁症相关研究的重复实验，可以获得重复性强的实验结果。